It is reasonable to speculate that migrainous infarction may develop in different territories of cerebral arteries. However, this condition was rarely reported before. Here we described two patients (one woman, 29 year-old; one man, 47 year-old) with a history of migraine with aura, had ischemic strokes during the migraine attack. The ischemic stroke of the female patient involved the territori...

We studied the elastic skeleton of major cerebral arteries in rats, monkeys, and one human using scanning electron microscopy after hot formic acid extraction followed by freeze-drying. For comparison, we also examined the thoracic aorta and femoral artery of rats. The cerebral arteries of rats had one distinct internal elastic lamina connected to the thin adventitia with sponge-like medial ela...

Primary vasculitis of the central nervous system (PACNS) is a rare form unknown cause that affects vessels brain, spinal cord and meninges without systemic damage. It was found average age onset disease 50 years. Clinical manifestations depend on caliber affected vessels. The most common initial symptoms are headache vascular cognitive impairment associated with small vessel involvement. develo...

The Effects of Increased Intracranial Pressure on Flow Through Major Cerebral A rteries In Vitro • The effect of transmural pressure (TMP) (intraluminal minus extraluminal pressure) on flow was measured for 26 isolated major cerebral arteries from human autopsies. The maximum flow rate through an artery was determined by the perfusion pressure (PP), the maximum vessel caliber, and the presence ...

OBJECTIVES Aortic arch disease can be treated with hybrid repair (extra-anatomic bypass plus placement of aortic endoprostheses), but there is controversy about whether a bypass from one relatively small vessel will provide adequate blood flow to the entire brachiocephalic system. We, therefore, compared flow volumes before and after hybrid repair. METHODS We reviewed the records of 16 patien...

Characterization of flow properties in cerebral arteries with 1.5 and 3 Tesla MRI is usually limited to large cerebral arteries and difficult to evaluate in the small perforating arteries due to insufficient spatial resolution. In this study, we assessed the feasibility to measure blood flow waveforms in the small lenticulostriate arteries with 7 Tesla velocity-sensitive MRI. The middle cerebra...

Previous studies report functional differences in large conductance Ca2+ activated-K+ channels (BKCa) of smooth muscle cells (VSMC) from rat cerebral and cremaster muscle resistance arteries. The present studies aimed to determine if this complexity in BKCa activity may, in part, be due to splice variants in the pore-forming α-subunit. BKCa variants in the intracellular C terminus of the α-subu...

Cerebral blood vessels contain both sympathetic and nitric oxide (NO) synthase (NOS)-containing nerves. NO has been proposed to modulate smooth muscle function and adrenergic nerve activity, and the nature of this modulation is controversial: some data show NO inhibits norepinephrine (NE) release, whereas others suggest that NO augments release. To test the hypothesis that in cerebral arteries ...

Background and Purpose Transcranial color-coded sonography is a new development in noninvasive cerebral vascular imaging. Reference data using this technique are described. Methods Blood velocities and pulsatility and resistance indices were determined in the anterior cerebral, middle cerebral, posterior cerebral, vertebral, and basilar arteries in 115 volunteers after correction for the angle ...

BACKGROUND AND PURPOSE Tirilazad mesylate has been used in the attempt to prevent cerebral vasospasm after subarachnoid hemorrhage (SAH), although the actual targets of this agent in vivo have thus far been controversial. Chemiluminescence/high-performance liquid chromatography provided a new method for direct measurements of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamin...