Fabry's disease is an X-linked lysosomal storage disorder. alpha-Galactosidase deficiency leads to accumulation of globotriaosylceramide mainly in endothelial and smooth muscle cells. Cerebrovascular symptoms with predominant affection of the vertebrobasilar circulation are one of the major sources of morbidity in Fabry's disease. We present a Hungarian family with Fabry's disease caused by a n...

The classic dynamic autoregulatory index (ARI), proposed by Aaslid and Tiecks, is one of the most widely used methods to assess the efficiency of dynamic cerebral autoregulation. Although this index is often used in clinical research and is also included in some commercial equipment, it exhibits considerable intra-subject variability, and has the tendency to produce false positive results in cl...

The effects of acetazolamied on the cerebral circulation and metabolism was previously shown to be due to a raised PCO2 in brain tissue. The effects of the drug on the human electroretinogram (ERG) are investigated in fifteen human volunteer subjects. A significant increase in the b-wave was found. A similitude with the mechanism of acetazolamide administration in brain and retinal tissue seems...

In this article we review basic and some advanced concepts of stroke imaging. The benefits and caveats of both CT and MRI are stressed and we attempt to familiarize the reader with current concepts regarding collateral brain circulation, its nature, and its importance in acute stroke.

The two minute slope method of measuring cerebral blood flow (CBF) by inhalation of 133Xe is described. It requires the subject to remain still for only two minutes and is thus applicable to a wide variety of patients and to investigations involving brief physiological stimuli. The influence of extracerebral blood flow on CBF calculated by this method has been studied. Results from the two minu...

Regional cerebral blood flow (CBF) was measured by an autoradiographic method in nine adult cats, using antipyrine-(14)C as a diffusible indicator. In seven of the cats, CBF measurements were made during stimulation of a cervical sympathetic trunk. Stimulation caused minor regional decreases of CBF in at least five of these seven cats. The decreases were non-uniform and occurred almost exclusiv...

THE EFFECT OF HYPOXAEMIA upon the cerebral blood flow (CBF) has been studied in anaesthetised animals, 1-:~ but only intravenous anaesthetic agents, usually pentobarbitone, have been investigated. No studies have been made of the effect of induced hypoxaemia upon Cur in animals under inhalational anaesthesia. The present study was undertaken to determine the effect of hypoxacmia upon CBF at two...

In normal dogs, bolus administration of a very high dose of mannitol (2 gm/kg) resulted in a small, transient increase in cerebral blood flow (CBF) of approximately 8 percent lasting less than 10 minutes followed by a significant reduction in CBF of approximately 20 percent lasting at least three hours. The increase in CBF may in part be related to changes in cardiovascular and hematological pa...

The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.

Abstract Background Obesity is a major health problem that affects different vascular systems, including cerebrovascular circulation. Carotid duplex the best screening tool for early diagnosis of changes in relation to risk factors obesity. The present study aims evaluate effect body mass index on parameters extracranial vessels healthy subjects using ultrasonography. Results intimal medial thi...