PURPOSE Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss a...

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DN...

OBJECTIVE The purposes of this study were to establish intracervical tumors of the nude rat as an orthotopic experimental model for human cervical cancer and to preliminary evaluate the effects of the adenoviral vector, Ad5CMV-p53, on orthotopic cervical tumor size. METHODS Human cervical cancer SiHa and ME-180 cells were injected into the cervix of the nude rat. Four days later, 1 x 10(9) pl...

e15518 Background: This study was carried out to highlight the prevalence of cancer of the uterine cervix and shortcoming in the management of cervical cancer in our hospital. There is the need to improve on our personnel training and equipment acquisition. METHODS This was a retrospective study. Case folders of forty-seven patients who were diagnosed with cancer of the cervix were retrieved ...

PURPOSE In clinical practice, radiation therapy often fails in cervical carcinoma stage IIIB and there is a need to develop a predictive assay for prognosis of radiation treatment outcome in cancer patient. We have attempted to evaluate the relevance of changes in Membrane Fluidity (MF) and associated apoptotic cell death in cervical cancer cells after first fractionated dose of radiation thera...

PURPOSE To proof feasibility of hydrogel application in patients with advanced cervical cancer undergoing chemo-radiation in order to reduce rectal toxicity from external beam radiation as well as brachytherapy. MATERIAL AND METHODS Under transrectal sonographic guidance five patients with proven cervical cancer underwent hydro gel (20 cc) instillation into the tip of rectovaginal septum adhe...

Background: Female genital schistosomiasis is a gynecological disease caused by Schistosoma haematobium. The uterine cervix appears to be the most affected area with cases found in sub-Saharan Africa. Though both males and females can affected, consequences of are more pronounced reported increased risk HIV transmission malignancy female genitalia. shares similarities presentation those cervica...

Apart from sarcoma of the uterus and chorionepithelioma which are both extreme-v rare, malignant disease of the uterus may be considered under two headings, cancer of the cervix and cancer of the body. In Bristol in 1950 cancer of the uterus accounted for 10 per cent, of female cancer deaths. In comparison breast cancer caused 17.4 per cent, of female cancer deaths.

HEALTH ISSUE: Cervical cancer is one of the most common malignant diseases of women; it is diagnosed in almost half a million women every year and half as many die from it annually. In Canada and other industrialized countries, its incidence has decreased due to cytology screening. However, invasive cases still occur, particularly among immigrant groups and native Canadian women. Although incid...

The overall five-year survival of cervical cancer is only 40% worldwide despite the development of effective screening modalities. Paramount to this issue is access to appropriate medical care which remains limited to high-risk populations throughout the world. While surgery and radiation remain the mainstays of current treatment, new therapies based on the association of cervical cancer with t...