Sensitive, simple, reliable and rapid HPLC technique for the estimation of simvastatin (SMV) and cetirizine has been designed in this study. The chromatographic conditions were set using Shimadzu LC-10 AT VP pump, with UV detector (SPD-10 AV-VP). System integration was performed with CBM-102 (Bus Module). Partitioning of components was attained with pre-packed C-18 column of Purospher Star (5 μ...

A previously healthy 8-year old boy was seen for a second opinion regarding a 1-year history of urticaria. The initial onset of generalized urticaria was noted 30 minutes after a dose of fexofenadine for seasonal allergy symptoms. He had tolerated fexofenadine in previous pollen seasons without any complications. Since onset, he has had daily generalized urticaria. After 2 months of symptoms de...

A validated simple, economic, selective, and stability indicating spectrofluorimetric method was developed for the determination of some antihistaminic H1 receptor antagonist drugs namely ebastine (EBS), cetirizine dihydrochloride (CTZ), and fexofenadine hydrochloride (FXD). The method is based on the reaction of the cited drugs with 2-cyanoacetamide in alkaline medium to give highly fluorescen...

Received: Revised: Accepted: 2013–09–31 2013–12–28 2013–12–29 A total of six horses were presented with severe generalized lesions including wheal with dermal edema, erythema, papules, pustules and angioedema. In one horse food hypersensitivity was found, while rest were diagnosed for idiopathic urticaria. Haridrakhand Brihat, which is a polyherbal combination containing haridra, nishoth, haree...

Eosinophils are abundant in inflammatory demyelinating lesions in neuromyelitis optica (NMO). We used cell culture, ex vivo spinal cord slices, and in vivo mouse models of NMO to investigate the role of eosinophils in NMO pathogenesis and the therapeutic potential of eosinophil inhibitors. Eosinophils cultured from mouse bone marrow produced antibody-dependent cell-mediated cytotoxicity (ADCC) ...

The objective of the present study was to prepare the fast disintegrating tablet of Salbutamol Sulphate, Cetirizine Hydrochloride in combined tablet dosage form for respiratory disorders such as bronchitis, asthma, and coughing for pediatrics and geriatrics. The tablets were prepared by direct compression technique. Superdisintegrant such as Sodium Starch Glycolate was optimized as 4% on the ba...