Mixing of materials by small scale turbulent motion is a critical element of many flow systems of interest in engineering, geophysics, and astrophysics. Numerical simulation plays a crucial role and turbulent mixing predictability is a major concern. Small scale resolution requirements focus typically on those of continuum fluid mechanics described by Navier–Stokes (NS) equations; different req...

BACKGROUND This proof of concept study was designed to evaluate the safety and effectiveness of a computerized insulin program, the Clarian GlucoStabilizer Subcutaneous Insulin Program (CGS-SQ). This paper discusses the CGS-SQ's impact on the glycemic control of hospitalized patients with hyperglycemia. METHODS Patients at Methodist and Indiana University Hospitals requiring subcutaneous insu...

The fertilization-induced exocytosis of egg cortical granules (CGs) is responsible for a block to polyspermy, crucial to the viability of many species. The contents of mammalian CGs have been an elusive target for analysis because of picogram quantities of CG proteins. By using media enriched in secreted CG contents from calcium ionophore-induced eggs as an immunogen, a monoclonal antibody was ...

STUDY OBJECTIVE To evaluate the effect of two forms of postnatal social support for disadvantaged inner city mothers on maternal and child health outcomes. DESIGN Randomised controlled trial with economic and process evaluations and follow up at 12 and 18 months. The two intervention groups received either the offer of a year of monthly supportive listening home visits by a support health vis...

Many marketed pharmaceuticals are known to cause idiosyncratic agranulocytosis in humans. Similarly prinomide, an antiinflammatory drug, was associated with a low incidence of agranulocytosis (<0.3%) in clinical trials, even though chronic toxicity studies in rodents and primates showed no evidence of agranulocytosis with either prinomide or its parahydroxy metabolite, CGS 12094. To investigate...

The main objective of this paper is to add one more brick in building the CG model as a knowledge representation model autonomous from logic. The CG model is not only a graphical representation of logic, it is much more: it is a declarative model encoding knowledge in a mathematical theory, namely labelled graph theory, which has eecient computable forms, with a fundamental graph operation on t...

CGS 16949A is a very potent and highly selective inhibitor of the aromatase enzyme system in vitro and of estrogen biosynthesis in vivo. These characteristics are reflected in the marked efficacy with which it affects growth of estrogen-dependent 7,12-dimethylbenz(a)antracene-induced mammary carcinomas in intact female Sprague-Dawley rats. Daily p.o. treatment of tumor-bearing rats for 42 days ...

The effects of neutral endopeptidase (NEP) in acute inflammation in the lung were studied using a newly developed murine model of smoke and burn (SB) injury. C57BL/6 mice were pretreated with an i.v. dose of a specific NEP antagonist CGS-24592 (10 mg/Kg) 1 h prior to SB injury (n = 5-8/group). Mice were anesthetized with i.p. ketamine/xylazine, intubated, and exposed to cooled cotton smoke (2 x...

INTRODUCTION This study aimed to assess psychological distress (PD) as scored by the Distress Thermometer (DT) in adult primary brain tumor patients and caregivers (CGs) in a clinic setting and ascertain if any high-risk subgroups for PD exist. MATERIAL AND METHODS From May 2012 to August 2013, n = 96 patients and n = 32 CG underwent DT screening at diagnosis, and a differing cohort of n = 12...

Thermally sprayed 316L stainless steel coatings are commonly used on metallic structures due to their corrosion and wear resistance when compared carbon steel. Cold Gas Spray (CGS) is a convenient thermal spray process deposit coatings, producing thick very dense with almost no deleterious changes the feedstock properties coating condition. The powder characteristics have influence microstructu...