This paper studies the competitive and cooperative selection of inventory policies in a two-echelon supply chain with one supplier and N retailers. Stochastic demand is monitored continuously. Retailers incur inventory holding and backorder penalty costs. The supplier incurs holding costs for its inventory and backorder penalty costs for backorders at the retailers. The latter cost reflects the...

BACKGROUND AND AIMS Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability in schizophrenia, aims to investigate associations between improvements in co...

The US National Research Council defines abrupt climate change as a change of state that is sufficiently rapid and sufficiently widespread in its effects that economies are unprepared or incapable of adapting. This may be too restrictive a definition, but abrupt climate change does have implications for the choice between the main response options: mitigation (which reduces the risks of climate...

We evaluated the economic efficiency as well as the clinical effectiveness on serum lipid levels of a change in drug therapy from bezafibrate or a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor to fenofibrate. Subjects were 26 outpatients suffering from type IIb or type IV hyperlipidemia who visited our hospital between October 2000 and January 2001. Medication doses, and s...

Ž . This paper investigates the significance of induced technological change ITC for the attractiveness of CO abatement policies. We use analytical and numerical general equilib2 rium models in which technological change results from profit-maximizing investments in R&D. We show that carbon abatement policies have very different impacts on R&D across industries, and do not necessarily raise the...

The impact of changes in health practices on medical claims costs between 1985-1987 and 1988-1990 was examined among 796 employees. Employees completed a health risk appraisal in 1985 and 1988 and were categorized into health risk levels. High-cost status and high-risk status were significantly associated at both times. The percentage of employees with high-risk status decreased from 31.8% to 2...

BACKGROUND Climate change has begun to negatively affect human health, with larger burdens projected in the future as weather patterns continue to change. The climate change-related health consequences of diarrhoeal diseases, malnutrition, and malaria are projected to pose the largest risks to future populations. Limited work has been done to estimate the costs of adapting to these additional h...

1 Climate change has the potential to impact long-term road pavement performance. Consequently, to 2 maintain pavements within the same ranges of serviceability as before, current pavement maintenance 3 strategies need to be re-assessed and, if necessary, changed. Changes in maintenance may lead to 4 different agency costs and user costs as a consequence. This paper commences by defining an 5 a...