Abstract INTRODUCTION Treatment of primary CNS lymphoma (PCNSL) has rapidly evolved, emphasizing improved efficacy while reducing neurotoxicity. PCNSL historically been considered a multifocal disease and many patients relapse after first-line therapy. We evaluated patterns in large cohort contemporarily treated patients. METHODS Consecutive at MSKCC between 1983-2020 were analyzed. T1 post-con...

In this work we consider statistical learning problems. A learning machine aims to extract information from a set of training examples such that it is able to predict the associated label on unseen examples. We consider the case where the resulting classification or regression rule is a combination of simple rules – also called base hypotheses. The so-called boosting algorithms iteratively find...

From large cardinals we show the consistency of normal, fine, κ-complete -dense ideals on Pκ( ) for successor κ. We explore the interplay between dense ideals, cardinal arithmetic, and squares, answering some open questions of Foreman. Most large cardinals are characterizable in terms of elementary embeddings between models of set theory that have a certain amount of agreement with the full uni...

The acid-base reactions between the rare-earth metal (Ln) tris(ortho-N,N-dimethylaminobenzyl) complexes [Ln(CH2C(H4NMe2-o)3] with one equivalent of the silylene-linked cyclopentadiene-amine ligand (C5Me4H)SiMe2NH(C6H2Me3-2,4,6) afforded the corresponding half-sandwich aminobenzyl complexes [{Me2Si(C5Me4)(NC6H2Me3-2,4,6)}Ln(CH2C6H4NMe2-o)(thf)] (2-Ln) (Ln=Y, La, Pr, Nd, Sm, Gd, Lu) in 60-87 % is...

The invertibility hypothesis for a monoidal model category S asks that localizing an S-enriched category with respect to an equivalence results in an weakly equivalent enriched category. This is the most technical among the axioms for S to be an excellent model category in the sense of Lurie, who showed that the category CatS of S-enriched categories then has a model structure with characteriza...

It is widely believed that the scientific enterprise of theoretical linguistics and the engineering of language applications are separate endeavors with little for their techniques and results to contribute to each other at the moment. In this paper, we explore the possibility that machine learning approaches to natural-language processing (NLP) being developed in engineering-oriented computati...

According to the most popular theories of intentionality, a family of theories we will refer to as “functional intentionality,” a machine can have genuine intentional states so long as it has functionally characterizable mental states that are causally hooked up to the world in the right way. This paper considers a detailed description of a robot that seems to meet the conditions of functional ...

The subject of this thesis is the development of a potentially simple, general and economical synthetic protocol for the potent antimalarial alkaloid febrifugine (1) and its analogues. In Chapter 1, the interesting history of 1, which includes a description of several reported total syntheses of 1, is discussed. Natural products derived from 1, as well as promising synthetic derivatives that di...

The formation and repair of c/s-diamminedichloroplatinum(ll) (c/s-DDP)-induced DNA cross-links in cells from a number of different mouse tissues, both normal and neoplastia, were com pared in three different populations of animals, tumor-free mice and mice bearing a transplanted fibrosarcoma (either FSa or NFSa) in their thighs. Groups of mice were given i.v. injections of 4-12-mg/kg doses of c...

For n a positive integer, Ln is the variety of `-groups satisfying the equation [x, y] = e. Many of the well known but striking features of the Ln varieties carry over to varieties satisfying the laws [x, y, z] = e and [x, y, y] = e, such as the structure of finitely generated subdirectly irreducible `-groups and the respective intersections with the representable variety. Some interesting exam...