Although the FDA revoked metastatic breast cancer (MBC) from bevacizumab (BEV) indication in 2011, BEV combined with paclitaxel has been written in the breast cancer NCCN guidelines. This systematic assessment was performed to evaluate the efficacy and safety of BEV + chemotherapy (CHE) for managing MBC. PubMed and EMBASE were searched for original articles written in English and published befo...

Background to series CHE Discussion Papers (DPs) began publication in 1983 as a means of making current research material more widely available to health economists and other potential users. So as to speed up the dissemination process, papers were originally published by CHE and distributed by post to a worldwide readership. The CHE Research Paper series takes over that function and provides a...

We propose a uniform solution based on Pomset Logic to several diierent syntactic phenomena in Natural Languages, and in particular topicalization, relative clauses, interrogative clauses, extraposi-tion, discontinuous constituents and cliticization. We show that Pomset Logic is expressive enough to describe all the linguistic transformations due to these phenomena, in the sense that all transf...

Three promoters have been identified as having potentially important regulatory roles in governing expression of the fla/che operon and of sigD, a gene that lies near the 3' end of the operon. Two of these promoters, fla/che P(A) and P(D-3), lie upstream of the >26-kb fla/che operon. The third promoter, P(sigD), lies within the operon, immediately upstream of sigD. fla/che P(A), transcribed by ...

BACKGROUND Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse cancer prognosis and leads to resistance to conventional anticancer treatments. We previously showed the involvement of Che-1/AATF (Che-1) in cancer cell survival under stress co...

La sofferenza silenziosa dell’abbandono precoce non elaborata scava rumorosamente anche nell’attitudine genitoriale soprattutto nella possibilità adottiva. Figli adottivi che creano a loro volta una famiglia di accoglienza adottiva trovano un potenziale traumatogeno pericoloso nel vivere dalla parte genitoriale una esperienza filiale conosciuta. A volte queste strutture familiari, che non sono ...

a la tía Chayo y al tío Beto " …Era la prima persona che dava ascolto a quello che dicevo " … " Buon signore, colui che non porge solo orecchio ai cortigiani, ma cerca di capire come pensano i suoi sudditi. " (Baudolino e Niceta)

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 5, May 2007 799 Jennifer Cuellar-Rodríguez,* Arturo Galindo-Fraga,* Víctor Guevara,* Carolina Pérez-Jiménez,* Luis Espinosa-Aguilar,* Ana Lilia Rolón,* Araceli Hernández-Cruz, * Esaú López-Jácome,* Miriam Bobadilla-del-Valle,* Areli Martínez-Gamboa,* Alfredo Ponce-de-León,* and José Sifuentes-Osornio* *Instituto Nacional de Ciencias ...