This manuscript is a complementary article to an accompanying paper, published in a forthcoming issue, which will give an overview on the central role of chelation in labelling radiocompounds; either for imaging and/or for radionuclide therapy. In order to facilitate a better understanding of the importance of Chelator-Based Imaging & Therapy, we will briefly discuss in this publication which i...

Heart disease is the leading cause of mortality and one of the main causes of morbidity in beta-thalassemia. Patients with homozygous thalassemia may have either a severe phenotype which is usually transfusion dependent or a milder form that is thalassemia intermedia. The two main factors that determine cardiac disease in homozygous β thalassemia are the high output state that results from chro...

Background: The most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. The aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in Mofid Hospital. Materials and Methods: There were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49...