نتایج جستجو برای: chemical synthesis

تعداد نتایج: 762625  

Journal: :Journal of the American Chemical Society 2004
K C Nicolaou Junliang Hao Mali V Reddy Paraselli Bheema Rao Gerasimos Rassias Scott A Snyder Xianhai Huang David Y-K Chen William E Brenzovich Nicolas Giuseppone Aurora O'Brate Paraskevi Giannakakou

As an especially unique target for chemical synthesis, diazonamide A has the potential to be constructed through a plethora of synthetic routes, each attended by different challenges and opportunities for discovery. In this article, we detail our second total synthesis of diazonamide A through a sequence entirely distinct from that employed in our first campaign, one whose success required the ...

Journal: :Journal of the American Chemical Society 2008
Ngoc T Vo Robert D M Pace Fionn O'Hara Matthew J Gaunt

The inherent reactivity and functionality stored within aromatic systems provide numerous possibilities for the synthesis of 3-D organic structures via dearomatization processes.1,2 Under oxidizing conditions, the dearomatization of orthoand para-substituted phenols forms cyclohexadienones,3 and these products have found widespread use in the chemical synthesis of natural products.4 Additionall...

Journal: :Nucleic acids research 1995
E H Ekland D P Bartel

In vitro selection can generate functional sequence variants of an RNA structural motif that are useful for comparative analysis. The technique is particularly valuable in cases where natural variation is unavailable or non-existent. We report the extension of this approach to a new extreme--the identification of a 112 nt ribozyme secondary structure imbedded within a 186 nt RNA. A pool of 10(1...

2015
Baohua Wang King Young Wong Xudong Xiao Tao Chen

The past two years have witnessed unprecedentedly rapid development of organic-inorganic halide perovskite-based solar cells. The solution-processability and high efficiency make this technology extraordinarily attractive. The intensive investigations have accumulated rich experiences in the perovskite fabrication; while the mechanism of the chemical synthesis still remains unresolved. Here, we...

Journal: :Molecules 2015
Christophe Len Gérald Enderlin

Modified nucleoside analogues are of great biological importance as antiviral and antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an aromatic ring in different positions of the glycone for their biological activity. Different chemical synthesis strategies for these targets are described in this review.

Journal: :Journal of natural products 1998
A F Barrero J E Oltra J A Poyatos D Jiménez E Oliver

In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 1...

Journal: :Methods 2013
E Railey White Timothy M Reed Zhong Ma Matthew C T Hartman

Here, we describe a strategy for synthesis of peptides with multiple unnatural amino acids (UAAs) using in vitro translation. Our method involves removing a natural amino acid and replacing it with an UAA variant in a reconstituted translation system. Whereas other systems require engineered components or chemical synthesis to charge UAAs onto tRNAs prior to translation, our strategy utilizes t...

2013
Donald Craig

Organic synthesis is widely regarded as having begun nearly two centuries ago, with Friedrich Wöhler’s 1828 discovery that ammonium cyanate could be converted into urea [2]. Since that seminal finding, chemical synthesis has advanced to extents which must have been unimaginable to its early practitioners. The numerous paradigm-shifts which have taken place throughout the history of synthesis ha...

2017
Junxiu Ma Juan Qi Xinyu Gao Chunhua Yan Tianlong Zhang Hongsheng Tang Hua Li

3,5-Diamino-1,2,4-triazole (DAT) became a significant energetic materials intermediate, and the study of its reaction mechanism has fundamental significance in chemistry. The aim of this study is to investigate the ability of online attenuated total reflection infrared (ATR-IR) spectroscopy combined with the novel approach of hybrid hard- and soft-modelling multivariate curve resolution-alterna...

Journal: :Journal of molecular biology 1995
W G Scott J T Finch R Grenfell J Fogg T Smith M J Gait A Klug

To find conditions for obtaining diffraction-quality crystals of a hammerhead RNA rapidly and reproducibly, we employed a "double screening" procedure in which we screened six different RNA synthetic constructs against 48 crystallization conditions using a newly devised sparse matrix. We obtained crystals immediately and diffraction-quality crystals of the sixth RNA construct within six months ...

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