Background: Patients with locally advanced rectal cancer are often considered for neoadjuvant chemoradiotherapy before resection. This presurgical treatment can have negative effects on physical fitness, muscle mass, and compliance, which negatively influence clinical outcomes. Objective: The aim of this study was to evaluate fitness skeletal mass after in single subjects cancer. Design: An obs...

BACKGROUND A surgical resection is currently the preferred treatment for esophageal cancer if the tumor is considered to be resectable without evidence of distant metastases (cT1-3 N0-1 M0). A high percentage of irradical resections is reported in studies using neoadjuvant chemotherapy followed by surgery versus surgery alone and in trials in which patients are treated with surgery alone. Impro...

BACKGROUND AND OBJECTIVE Clinical trials on docetaxel plus cisplatin (DDP) (TP regimen) in treating nasopharyngeal carcinoma (NPC) are still uncertain due to limited samples. This study was to compare the short-term efficacy and toxicity of induction chemotherapy with TP regimen followed by concurrent chemoradiotherapy with TP regimen versus DDP in treating locally advanced NPC. METHODS Fifty...

Nasopharyngeal carcinoma is a common malignancy in the Asian Chinese population. The first-line treatment for Stage III/IV disease has in recent times shifted from radiotherapy to that of concurrent chemoradiotherapy. The treatment is not infrequently associated with in-field complications. We describe a rare case of one such complication -- subdural empyema developing post-chemoradiotherapy in...

Introduction/Background The treatment options for resectable oropharyngeal (OP) carcinomas are diverse and include surgery, with or without postoperative radiation therapy (PORT)/chemoradiotherapy (based on pathologic findings and patient factors), or definitive radiation therapy/chemoradiotherapy with or without adjuvant surgery (based on posttreatment imaging or biopsy findings). There is no ...

Although it has been shown in murine models that chemoradiotherapy may induce immunogenic tumor cell death, which could trigger T-cell immunity upon the released of high-mobility group box 1 protein (HMGB1), whether this also occurs in clinical settings remains unclear. Here, we discuss tumor-antigen specific T-cell responses in esophageal cancer patients receiving chemoradiotherapy. Our findin...

OBJECTIVE To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. METHODS Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reprod...

OBJECTIVES/HYPOTHESIS To analyze outcomes among patients with residual positron-emission tomography (PET)-negative lymphadenopathy after chemoradiotherapy for head and neck cancer based on whether or not they underwent neck dissection. STUDY DESIGN Retrospective review. METHODS Fifty-five patients with stage III/IV squamous cell carcinoma of the head and neck were identified with residual P...

Cervical cancer is very common among females. Surgery, chemotherapy and radiotherapy are different treatment options for cervical cancer. In 2018, the FIGO staging system has implemented lymph node status in criteria but didn’t consider number of positive nodes. The current guidelines recommends primary chemoradiotherapy to treat advanced stages combined regimens remains controversial, so this ...

needle aspiration biopsy is performed first and in case of failure, a diagnosis is made on the basis of surgical excision biopsy. Herein, we report a case of mucinous adenocarcinoma arising from chronic anal fistula that was successfully treated by neoadjuvant concurrent chemoradiotherapy followed by surgical management. In this case, a diagnosis was made on the basis of transrectal punch biops...