Cholera causes significant morbidity and mortality worldwide. For travelers, the risk of developing cholera per month of stay in a developing country is approximately 0.001%-0.01%, and cholera may present as traveler's diarrhea. In the United States, only a poorly tolerated, marginally effective, parenterally administered, phenol-inactivated vaccine is available. Outside the United States, 2 ad...

Cholera is an intestinal disease and is characterized by diarrhea and severe dehydration. While cholera has mainly been eliminated in regions that can provide clean water, adequate hygiene and proper sanitation; it remains a constant threat in many parts of Africa and Asia. Within this paper, we develop an agent-based model that explores the spread of cholera in the Dadaab refugee camp in Kenya...

The existence of Vibrio cholera (V. cholera) is a major health problem in many parts the world; therefore, treatments V. have always remained necessary for public safety, health, and environmental protection. In last few decades, plasma discharges proven to be novel technique sterilization against infectious bacteria such as cholera. this research, low-pressure (LPP) has been introduced degrada...

BACKGROUND The seasonality of cholera is described in various study areas throughout the world. However, no study examines how temporal cycles of the disease vary around the world or reviews its hypothesized causes. This paper reviews the literature on the seasonality of cholera and describes its temporal cycles by compiling and analyzing 32 years of global cholera data. This paper also provide...

Cholera toxin is normally observed only in the Golgi apparatus and not in the endoplasmic reticulum (ER) although the enzymatically active A subunit of cholera toxin has a KDEL sequence. Here we demonstrate transport of horseradish peroxidase-labeled cholera toxin to the ER by electron microscopy in thapsigargin-treated A431 cells. Thapsigargin treatment strongly increased cholera toxin-induced...

Natural cholera toxoid appears to act as a competitive inhibitor of cholera enterotoxin and is thus a useful tool for studying the interaction of cholera enterotoxin with cell membranes. Cholera enterotoxin binds to gut mucosa more rapidly than does its natural toxoid. Once binding occurs, however, it appears to be prolonged for both materials. Formalinized cholera toxoid has no inhibitory effe...

The effect of cholera toxin on activation of adenylate cyclase by the endogenous Ca2+-binding protein, calmodulin, GTP, dopamine, and forskolin was investigated in bovine striatum. Adenylate cyclase activity was measured in washed membrane fractions prepared from homogenates that had been preincubated with cholera toxin. Pretreatment of striatal membranes with cholera toxin increased the respon...

osteoporosis is the most common metabolic bone disease. in addition to morbidity, osteoporotic fractures also increase mortality risk in affected patients. enough evidence is not available to indicate that, like western countries, osteoporosis is a public health problem in iran. therefore emrc planned to estimate the burden of osteoporotic fractures in year 2001 based on existing sources of dat...

The paper presents a hypothesis that the most probable cause of death ancient world Indus (Harappa) civilization was epidemic Asiatic cholera. A brief description existed for two millennia (3300–1300 BC) is given. It shown previously described factors decline thriving (climate change, shallowing river and reduction in floods, catastrophic drought, economic crisis, etc.) do not provide consisten...