PURPOSE Choroidal neovascularization plays an important role in pathogenesis of age-related macular degeneration. Induction of neovascularization by laser photocoagulation in the rat fundus is an established animal model in which the effects of new therapeutic approaches are assessed. The purpose of this study was to compare different detection methods of laser-induced neovascularization in the...

Purpose Choroidal osteomas are benign intraocular tumors that classically present in females. Despite their benign nature, significant visual acuity loss can occur due to retinal pigment epithelium degeneration. We report an unusual case of bilateral choroidal osteoma in a young boy. Observation A 16 year old boy presented to the Aga Khan University Hospital with a history of painless, bilate...

OBJECTIVE To describe the vascular nature and clinical features of idiopathic polypoidal choroidal vasculopathy in Japanese patients. METHODS Patients thought to have idiopathic polypoidal choroidal vasculopathy were examined with binocular ophthalmoscopy, slitlamp biomicroscopy with a contact lens, fluorescein angiography, and indocyanine green angiography. RESULTS From January 1993 to Dec...

We report a case of a Caucasian female who developed active polypoidal choroidal vasculopathy (PCV) at the edge of a stable choroidal nevus and was successfully treated with verteporfin photodynamic therapy. No active polyp was detectable on indocyanine green angiography 2 years after treatment, and good vision was maintained. Indocyanine green angiography is a useful investigation to diagnose ...

BACKGROUND The aim of our study was to evaluate the functional and anatomic outcomes of intravitreal ranibizumab for the treatment of symptomatic drusenoid pigment epithelial detachment without choroidal neovascularization in age-related macular degeneration. METHODS This was a prospective, single-center, uncontrolled, interventional pilot study. Six consecutive eyes (six patients) with druse...

OBJECTIVE To describe the characteristics of incident choroidal neovascularization (CNV) in observed and treated eyes in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). DESIGN Cross-sectional descriptive study within a multicenter, randomized clinical trial. PARTICIPANTS Patients who developed CNV during CAPT follow-up. METHODS Inclusion criteria for CAPT sp...

Diabetic retinopathy and age-related macular degeneration are the leading causes of blindness in Western populations. Although it is a matter of controversy, large-scale population-based studies have reported increased prevalence of age-related macular degeneration in patients with diabetes or diabetic retinopathy. We hypothesized that metabolic syndrome, one of the major risk factors for type ...

PURPOSE To describe the clinical characteristics of a subset of eyes with neovascular age-related macular degeneration (NVAMD) receiving intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy which retain good visual acuity despite chronic, persistent subfoveal subretinal fluid (SRF). DESIGN Retrospective, observational case series. METHODS Study eyes were identified from ...

Choroidal osteoma is a rare intraocular bony tumor that typically manifests as a yellow-white, well-demarcated mass with geographic pseudopodal margins.1-3 This benign tumor predominantly occurs in the peripapillary or papillomacular region, most often in young women.1,2 Occasionally, choroidal osteoma can simulate an amelanotic choroidal tumor such as melanoma, nevus, or metastasis.1,2 This tu...