نتایج جستجو برای: chromosomal aberrations
تعداد نتایج: 57831 فیلتر نتایج به سال:
Although most of the vaccines are prepared out of the heat killed or attenuated virus and bacteria, study on their genotoxicity/clastogenicity is meagre. Therefore, the clastogenic potential of certain widely used vaccines namely, measles, rubella and rabies (rabipur), has been assessed at 24 h post-treatment from mouse bone marrow cells after a low dose, single intraperitoneal treatment. Mitot...
The effects of commercial formulations Viburnum opulus and Equisetum arvense extract on anti-cytotoxicity anti-genotoxicity were evaluated at the root tip Allium cepa L. Distilled water (negative control), dimethyl sulfoxide (DMSO), ethyl methane sulfonate (EMS, positive 5% 10% doses V. E. extracts applied for 24 48 hours. Cytotoxicity genotoxicity by calculating %mitotic index %chromosomal abe...
PURPOSE The present study was conducted to test the susceptibility of the mouse foetus to transmit chromosomal instability to the haemopoietic stem cells of offspring after in utero X-or plutonium-239-irradiation. MATERIALS AND METHODS Pregnant CBA/Ca-mice were injected with 80 kBq/kg 239Pu or X-irradiated with 1 Gy X-rays on days 13 or 14 of gestation. CFU-A cultures were grown from haemopoi...
background: cyclophosphamide (cyp) is used to treat a wide range of human tumors. however, the mutagenic effect of cyp is still the primary limitation for wider applications to treat a variety of human malignancies. it has been reported that cyp entrapped in liposomes reduces non-specific toxicity and enhances anticancer effects in animal systems. methods: in the present experiment, mice were i...
BACKGROUND Patients with syndromic features frequently suffer from recurrent respiratory infections, but little is known about the spectrum of immunological abnormalities associated with their underlying chromosomal aberrations outside the well-known examples of Down and DiGeorge syndromes. Therefore, we performed this retrospective, observational survey study. METHODS All members of the Euro...
BACKGROUND & OBJECTIVE Myelodysplastic syndrome (MDS) represents a group of clonal haematological disorders characterized by progressive cytopenia reflecting defects in erythroid, myeloid and megakaryocytic maturation. The incidence of MDS is more in older age groups and frequent chromosome abnormalities reported to be monosomies 5 and 7. However, the data on cytogenetic changes in Indian MDS p...
Gene mutations are essential to carcinogenesis. If an evident difference is observed in gastric mucosal chromosomal structure aberrations between H. pylori (Hp)-negative and Hp-positive gastric cancer patients, it may be interpreted as suggesting the involvement of Hp in gene mutations. This study was undertaken to compare chromosomal structural aberrations between Hp-negative and Hp-positive g...
Goeckerman's therapy (GT), which combines exposure to coal tar (polycyclic aromatic hydrocarbons - PAHs) and UV radiation (UV) is often used as the first option for treatment of psoriasis. However, PAHs and UV represent mutagenic, carcinogenic and immunotoxic agents. Therefore GT can represent a health risk for the patients. The group under observation consisted of thirty patients undergoing GT...
Changes in the toxicity in chlorinated water after chlorine addition were examined. For toxicity evaluation, the chromosomal aberration test and the transformation test were conducted as indexes of initiation activity and promotion activity, respectively, in the carcinogenesis process. Activity inducing chromosomal aberrations in chlorinated Lake Biwa water gradually decreased over time after c...
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