نتایج جستجو برای: chromosome study

تعداد نتایج: 4058431  

Journal: :iranian journal of radiation research 0
s. hosseini novin medical radiation institute, tehran, iran h. mozdarani

background: premature chromosome condensation (pcc) is a method for interphase chromosome analysis in biodosimetry. this study was performed to verify the usefulness of pcc induced by calyculin a in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. materials and methods: peripheral blood was obtained from a healthy donor and expo...

Journal: :Bioinformatics 2010
Rick Twee-Hee Ong Yik-Ying Teo

MOTIVATION Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and ...

2011
Jin Liu Kai Wang Shuangge Ma Jian Huang

We use a novel penalized approach for genome-wide association study that accounts for the linkage disequilibrium between adjacent markers. This method uses a penalty on the difference of the genetic effect at adjacent single-nucleotide polymorphisms and combines it with the minimax concave penalty, which has been shown to be superior to the least absolute shrinkage and selection operator (LASSO...

2016
Yunpeng Wang Wesley K. Thompson Andrew J. Schork Dominic Holland Chi-Hua Chen Francesco Bettella Rahul S. Desikan Wen Li Aree Witoelar Verena Zuber Anna Devor Markus M. Nöthen Marcella Rietschel Qiang Chen Thomas Werge Sven Cichon Daniel R. Weinberger Srdjan Djurovic Michael O’Donovan Peter M. Visscher Ole A. Andreassen Anders M. Dale Greg Gibson

Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy) for each single nucleotide polymorphism (SNP) to enable more accurate estimation of replication...

2014
Wei Wang Jiao Lou Xu-zai Lu Yan-qi Qi Na Shen Rong Zhong Yu-jia Wang Li Zou Qing Zhang Jia-yu Duan Jun-tao Ke Xiao-ping Miao Fang-qi Gong

8p22-23-rs2254546 was firstly discovered to be associated with Kawasaki disease (KD) susceptibility by a genome-wide association study. However, only one Chinese replication study has been performed so far. To verify this association in another Chinese population, a hospital-based case-control study in Zhejiang province was conducted followed by an integrated meta-analysis, comprising five case...

2013
Dayanidhi Kumar Sujith Raj Salian Guruprasad Kalthur Shubhashree Uppangala Sandhya Kumari Srinivas Challapalli Srinidhi Gururajarao Chandraguthi Hanumanthappa Krishnamurthy Navya Jain Pratap Kumar Satish Kumar Adiga

BACKGROUND Cytogenetic studies have demonstrated that low levels of chronic radiation exposure can potentially increase the frequency of chromosomal aberrations and aneuploidy in somatic cells. Epidemiological studies have shown that health workers occupationally exposed to ionizing radiation bear an increased risk of hematological malignancies. OBJECTIVES To find the influence of occupationa...

2007
GORDON HEIER G. HEIER

We apply Nadel’s method of multiplier ideal sheaves to show that every complex del Pezzo surface of degree at most six whose automorphism group acts without fixed points has a Kähler-Einstein metric. In particular, all del Pezzo surfaces of degree 4, 5, or 6 and certain special del Pezzo surfaces of lower degree are shown to have a Kähler-Einstein metric. This result is not new, but the proofs ...

2017
Adam P. Sage Brenda C. Minatel Kevin W. Ng Greg L. Stewart Trevor J.B. Dummer Wan L. Lam Victor D Martinez

Chronic exposure to arsenic affects more than 200 million people worldwide, and has been associated with many adverse health effects, including cancer in several organs. There is accumulating evidence that arsenic biotransformation, a step in the elimination of arsenic from the human body, can induce changes at a genetic and epigenetic level, leading to carcinogenesis. At the genetic level, ars...

Journal: :Human heredity 2010
Andrew S Allen Glen A Satten Sarah L Bray Frank Dudbridge Michael P Epstein

Genome-wide association studies (GWASs) aim to genotype enough single nucleotide polymorphisms (SNPs) to effectively capture common genetic variants across the genome. Even though the number of SNPs genotyped in such studies can exceed a million, there is still interest in testing association with SNPs that were not genotyped in the study sample. Analyses of such untyped SNPs can assist in sign...

Journal: :journal of sciences islamic republic of iran 0

down syndrome is one of the most common causes of mental retardation observed in approximately 1/700 live birth. the use of two or more str markers related to chromosome 21 facilitates the diagnosis of down syndrome within about six hours from the collection of the samples. this is the first study has been performed in iranian population to assess the diagnostic value of using small tandem repe...

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