immunodeficiency and autoimmune disease may occur concomitantly in the same individual. some of the immunodeficiency syndromes, especially humoral defects are associated with autoimmune disorders. hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations. persistent antigen stimulation due to an inherent defect in the ability of the immune syst...

chronic  granulomatous  disease (cgd)  is a rare primary immunodeficiency disorder characterized by a greatly increased susceptibility to severe fungal and bacterial infections caused  by  defects  in  nadph   oxidase  of  phagocytic  cells. we  aimed  to  investigate immunophenotype alterations of naïve and memory b cells and b1a cells in peripheral whole blood from iranian patients with cgd. ...

chronic granulomatous disease is an inherited defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections including invasive aspergillosis in early childhood. we report  a  disseminated aspergillosis as  the  representative  of  adult  onset  chronic granulomatous disease without previous infection, with dramatic respons...

background: chronic obstructive pulmonary disease (copd) is considered a major public health problem in the world. weight loss, muscle and fat mass depletion are common nutritional problems in copd patients and are determinant factors in pul­monary function, health status, disability and mortality. in the present study, we assessed nutritional status in copd pa­tients. methods: this cross-secti...

Background: In this study, we aimed to assess the prevalence of comorbidities in the confirmed COVID-19 patients. Thismight help showing which comorbidity might pose the patients at risk of more severe symptoms.Methods: We searched all relevant databases on April 7th, 2020 using the keywords (“novel coronavirus” OR COVID-19OR SARS-CoV-2 OR Coronavirus) AND (comorbidities OR cl...

background : the aim of this study was to investigate the association between the two most commonly used generic and disease specific health-related quality of life (hrqol) measures in patients with chronic lung disease due to sm: medical outcomes study short form 36-item (sf-36) and st george's respiratory questionnaire (sgrq). methods : this is a secondary analysis of iranian chemical warfare...

Background: The parent’s awareness about chronic disabling disease in their children definitely distresses the parents. Children of such parents show behavior & cognitive disturbances with long term negative impact on the family. Objective: The present study was carried out to investigate the prevalence of depression in parents of disabled children. Methods: Following a cross-sectional study, 5...