Hepatitis B virus splice-generated protein (HBSP), encoded by a spliced hepatitis B virus RNA, was recently identified in liver biopsy specimens from patients with chronic active hepatitis B. We investigated the possible generation of immunogenic peptides by the processing of this protein in vivo. We identified a panel of potential epitopes in HBSP by using predictive computational algorithms f...

Background: Hepatitis B surface antigen (HBsAg) is one of the main proteins of HBV envelop and its serum quantitative measurement is the most common quantitative test for monitoring the progress of Chronic Hepatitis B. Although measurement of serum HBV DNA copy number is a gold standard method for displaying viral load, the test is relatively expensive and it is not readily available everywhere...

conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at...

Chronic hepatitis B infection is a global health problem that affects about 300 million people. Of these, 75% are Chinese. Most Chinese who become chronic carriers, contract the virus during the perinatal period. The natural history of these chronic hepatitis B carriers includes an initial immune tolerance phase, followed by immune clearance and an inactive hepatitis B non-replicative phase wit...

conclusions fulminant hepatitis b is associated with distinct mutational patterns of hbv, underlining that genomic diversity of the virus is an important factor determining its pathogenicity. results the most commonly detected diversities affect regulatory motifs of hbv in the core and s region, indicating that these alterations may convert the virus to an aggressive strain. moreover, mutations...

results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...

BACKGROUND/AIMS Specific T cell responses during acute hepatitis B and during chronic hepatitis C have been described in detail. However, the T cell responses during the rare setting of acute hepatitis B virus (HBV) infection in the course of chronic hepatitis C that eventually lead to clearance of both viruses are completely unknown. METHODS We analyzed the virus specific CD4+ and CD8+ T cel...