Chronic obstructive pulmonary disease is an inflammatory disease. Together with oxidant stimuli, which directly affect lung structures, macrophages, neutrophils and CD8+ lymphocytes actively participate in the pathogenesis of the disease and promote biochemical reactions that result in progressive alteration of the upper airways and irreversible lung remodeling. The release of substances promot...

CFTR is a cAMP-activated chloride and bicarbonate channel that is critical for lung homeostasis. Decreases in CFTR expression have dire consequences in cystic fibrosis (CF) and have been suggested to be a component of the lung pathology in chronic obstructive pulmonary disease. Decreases or loss of channel function often lead to mucus stasis, chronic bacterial infections, and the accompanying c...

The physiological hallmark of chronic obstructive pulmonary disease (COPD) is expiratory flow limitation. However, it is the resultant air trapping and associated increases in lung volume (hyperinflation) that provide a mechanistic link between the physiological impairment and the characteristic symptoms of COPD, such as dyspnoea (breathlessness), exercise intolerance and reduced health-related...

A decreased inspiratory capacity (IC)/total lung capacity (TLC) ratio is associated with dynamic hyperinflation and decreased exercise capacity. The present authors hypothesised that static (low IC/TLC) and dynamic hyperinflation impair cardiac function as assessed by oxygen pulse at rest and during cardiopulmonary exercise testing (CPET). Lung function, body mass index, hand grip strength and ...

BACKGROUND Although impaired lung function in general has been associated with an increased risk of lung cancer, past studies typically have not attempted to investigate separately the obstructive and restrictive components of respiratory impairment. To deal with this question further, data from a large (n = 176 997) cohort of male Swedish construction workers, for whom spirometry measurements ...

Obstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med 2000;160:1683–9. 11. Shahab L, Jarvis MJ, Britton J, et al. Chronic obstructive pulmonary disease prevalence, diagnosis and relation to tobacco dependence in a nationally representative population sample. Thorax 2006;61:1043–7....

Atmospheric aerosols are one of the main pollutants which harmful to human health and environment. emitted from different sources sizes depending upon size aerosol particle, it deposits in parts body cause varying problems. Fine Particulate (PM2.5) is associated with more severe consequences than coarse particulate (PM10) might be short-term acute symptoms like coughing, shortness breath, wheez...

Pneumomediastinum, defined as the presence of air in mediastinum often occurs due to trauma, mechanical ventilation or surgical procedure. It may also occur spontaneously predisposing lung diseases such asthma and Chronic obstructive pulmonary airway disease (COPD). In this report, we present a case patient with COVID-19 pneumonia without any underlying conditions usual risk factors for pneumom...

introduction: chronic obstructive pulmonary disease (copd) secondary to sulfur mustard gas poisoning, known as mustard lung, is a major late pulmonary complications in chemical warfare patients. serious comorbidities like dyslipidemia are frequently encountered in copd. the aim of this study was to measure the serum lipid profile and evaluate the relation of lipid parameters with the severity o...

The occupational contribution to chronic obstructive pulmonary disease (COPD) has yet to be put in a global perspective. In the present study, an ecological approach to this question was used, analysing group-level data from 90 sex-specific strata from 45 sites of the Burden of Obstructive Lung Disease study, the Latin American Project for the Investigation of Obstructive Lung Disease and the E...