To provide high-quality guideline-based care for patients with asthma or chronic obstructive pulmonary disease (COPD) we must first establish the correct diagnosis. The National Asthma and COPD Audit Programme (NACAP) has highlighted an important issue across England, Scotland, Wales that potentially undermines many people airways disease.

Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by slow progression and caused the inhalation of harmful particulate matter. Cigarette smoke air pollutants are primary contributing factors. Currently, pathogenesis COPD remains incompletely understood. The PI3K/Akt signaling pathway has recently emerged as critical regulator inflammation oxidative stre...

Idiopathic pulmonary arterial hypertension (IPAH) has been extensively investigated, although it represents a less common form of the pulmonary hypertension (PH) family, as shown by international registries. Interestingly, in types of PH that are encountered in parenchymal lung diseases such as interstitial lung diseases (ILDs), chronic obstructive pulmonary disease (COPD), and many other diffu...

Chronic obstructive pulmonary disease (COPD) represents an increasing burden throughout the world. COPD-related mortality is probably underestimated because of the difficulties associated with identifying the precise cause of death. Respiratory failure is considered the major cause of death in advanced COPD. Comorbidities such as cardiovascular disease and lung cancer are also major causes and,...

Background and Aim: Although asthma chronic obstructive pulmonary disease (COPD) are clinically distinct diseases, they represent biologically diverse overlapping clinical entities it has been observed that often co-occur. Some research theorizing suggest there is a common comorbid condition termed asthmachronic overlap (ACO). However, the existence of ACO controversial.Material Methods: This ...

microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. After great development in the knowledge of pulmonary arterial hypertension (PAH) during the last decades, there is now an increasing interest in the pathophysiology of other forms of pulmonary hypertension, such as chronic obstructive pulmonary disease (COPD). The results obtained in t...

Asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases with high prevalence in the general population. Asthma affects 25 million Americans (18 million adults and 7 million children) (1), while about 14.2 million Americans are diagnosed with COPD and 9.8 million are estimated to have COPD that is undiagnosed (2, 3). A variable degree of airway inflammation, airway obstructi...

TYPE: Abstract TOPIC: Obstructive Lung Diseases PURPOSE: To investigate the protective roles of adipose-derived stem cells-derived exosomes (ADSCs-Exo) in cigarette smoke (CS)-induced COPD and explore underlying mechanism by discovering effects ADSCs-Exo on alveolar macrophages (AMs) pyroptosis. METHODS: ADSCs were isolated from human adipose tissues, then isolated. 24 8-week-old male C57/BL6 m...

M any lung diseases, such as severe asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis and infiltrative pulmonary diseases are associated with chronic neutrophilic inflammation. These diseases are common, can be severe and, together, represent a major economic burden and worldwide public health challenge. In addition to chronic handicap, these diseases al...