The occupational contribution to chronic obstructive pulmonary disease (COPD) has yet to be put in a global perspective. In the present study, an ecological approach to this question was used, analysing group-level data from 90 sex-specific strata from 45 sites of the Burden of Obstructive Lung Disease study, the Latin American Project for the Investigation of Obstructive Lung Disease and the E...

Pulmonary emphysema, as a feature of chronic obstructive pulmonary disease (COPD), is characterised by destruction of alveolar tissue. The present authors previously demonstrated reduced decorin expression in the peribronchial area of COPD patients, reflecting an altered extracellular matrix (ECM) modulation. Decorin transcription is regulated by the transforming growth factor (TGF)-beta-Smad p...

Interleukin (IL)-18 production and pulmonary function were evaluated in patients with chronic obstructive pulmonary disease (COPD) in order to determine the role of IL-18 in COPD. Immunohistochemical techniques were used to examine IL-18 production in the lungs of patients with very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV, n = 16), smokers (n = 27) an...

Bronchoscopy with bronchoalveolar lavage (BAL) is an important research tool for assessing airway inflammation in a variety of inflammatory lung diseases. In chronic obstructive pulmonary disease (COPD), BAL recovery is often low, making analysis of the recovered fluid difficult to interpret. The present authors hypothesised that the degree of emphysema may predict BAL recovery. A total of 20 C...

Chronic obstructive pulmonary disease (COPD) is defined as a disorder characterised by expiratory airflow limitation that is not fully reversible [1]. The airflow limitation is usually slowly progressive and associated with an inflammatory response of the lungs to noxious particles or gases. The airflow obstruction may be caused by structural alterations and/or functional factors. COPD, related...

III Einstein International Symposium on Intensive Care and the XXX Mechanical Ventilation. Aug 16-18, 2023. Category: Pneumology Introduction: Musculoskeletal dysfunction results in disability mortality patients with Chronic Obstructive Pulmonary Disease (COPD). () Body mass, weight height influence quadriceps muscle thickness. Thus, thigh sonographic index (IST) becomes a reliable parameter as...

Recently, it has been shown that the accumulated volume of B-cells in small airways is increased in chronic obstructive pulmonary disease (COPD) Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 3 and 4. Little is known about the number of B-cells in central airways in COPD. The present authors hypothesised that the number of B-cells in bronchial biopsies of large airways is ...

Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the prot...

This study assessed the feasibility of pulmonary telerehabilitation’s (PTR) acceptability, implementation, practicality, and adaptation for people with Chronic Obstructive Pulmonary Disease (COPD) in Brazil. It also explored associations clinical socioeconomic features Brazilians COPD. mixed-method included thirty-one participants COPD (age 62±10 years; FEV1= 72±14% predicted). Most (74.2%) rep...