MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when ...

Leprosy is a rare but important infectious disease caused by mycobacterium leprae. Word health organization suggested a strategy to reduce the prevalence of the disease to less than one per 10000 people. It seems that the leprosy is now in its elimination stage because during a period of ten years only few new cases were found in Iran. We studied 157 new leprosy cases that were referred to and ...

AIM The aim of the work was the presentation of one case with Acrodermatitis enteropathica. METHODS Acrodermatitis enteropathica is diagnosed based on the pedigree, typical clinical manifestations on the skin, laboratory results, small bowel biopsy, skin biopsy and kariotype. RESULTS The patient was a two years old male toddler, hospitalized due to skin changes, chronic diarrhoea and total ...

Atopic Dermatitis is a chronic inflammatory skin disease that affects a large number of children and adults. The disease results from an interaction between genetic predisposition, host environment, skin barrier defects, and immunological factors. A major aggravating factor associated with Atopic Dermatitis is the presence of microorganisms on the patient's skin surface. Staphylococcus aureus a...

background :chronic obstructive pulmonary disease (copd) is a third leading cause of death.   methods : in this case control study, we prepared 5 cc bloods from the antecubital vein of 100 copd patients and 40 healthy individuals as control group. vascular endothelial growth factor (vegf) expression protein level was measured by elisa in both groups.   results : we found that concentration of v...

OBJECTIVE This study aims to evaluate the relationship between tissue advanced glycation end products, as reflected by skin autofluorescence, and vascular calcification in chronic kidney disease. APPROACH AND RESULTS Three hundred patients with stage 3 to 5 chronic kidney disease underwent multislice computed tomography to estimate total coronary artery calcium score (CACS) and had tissue adv...

Introduction Juvenile dermatomyositis (JDM) is a rare chronic, autoimmune vasculopathic disease with mainly muscle and skin involvement. The incidence described in USA is 2.5-4.1 cases per million children; the disease is slightly more common in girls. Recent studies describe that two third of the patients followed a chronic disease course, whereas only one third showed monocyclic disease course.

background: sulfur mustard is one of the chemical warfare gases that has been known as a vesicant or blistering agents. it is a chemical alkylating compound agent that can be frequently absorbed through skin, respiratory system, genital tract, and ocular system. this study was done to pathologically analyze the microscopic pancreatic lesions in cadavers. methods: this case series study was perf...

Inflammatory skin diseases are difficult to treat because of a lack of available treatment options for severe disease. However, recent advances have shown that vagus nerve stimulation can be used to decrease inflammation and reduce disease severity in rheumatoid arthritis and inflammatory bowel disease. Changes in cytokine profiles observed in these studies are similar to those seen with use of...

leprosy is a rare but important infectious disease caused by mycobacterium leprae . word health organization suggested a strategy to reduce the prevalence of the disease to less than one per 10000 people. it seems that the leprosy is now in its elimination stage because during a period of ten years only few new cases were found in iran. we studied 157 new leprosy cases that were referred to and...