LAUDEXIUM METHYLSULPHATE (Laudolissin) is a synthetic curarizing agent (Taylor and Collier, 1951) used in prolonged surgical operations. We have previously described some of its pharmacological properties (Collier and Macauley, 1952) and the purpose of the present paper is to report a further exploration of its pharmacology in relation to its clinical use. As Bovet (1951) has stressed, the toxi...

Gastrointestinal (GI) and genitourinary (GU) toxicity was assessed during and after conventional IMRT in 21 low to intermediate risk cancer patients that had received an absorbable hydrogel spacer between the prostate and the rectum. The transperineal hydrogel injection resulted in the creation of 11.5 mm space between the prostate and rectum; space that was not decreased throughout radiotherap...

Toxicity from digitalis is a typical clinical issue. In this case, the interaction of digoxin and furosemide becoming more widely recognised as major cause toxicity. We present an abnormal ECG that demonstrates digoxin-induced cardiotoxicity. report case Digoxin toxicity in 79-year-old male patient admitted with complains nausea, increase frequency micturition, decrease appetite, nocturia, shor...

In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs) as well as grouping (category formation) allowing for read-across. A challenging area for in silico modelling is the prediction of chronic toxicity and the No Observed (Adverse) Effect Level (NO(A)EL) in particular. A proposed solution to the prediction of chronic toxicity is to co...

In the present study, the safety profile of Trichosanthes dioica root was evaluated by acute and sub-chronic toxicity study of the hydro alcoholic extract of T. dioica root (TDA) in Swiss albino mice. The oral median lethal dose (LD ) of TDA was found to be 2800 mg/kg body weight. For sub-chronic toxicity study 50 TDA was administered at the single daily dose of 10 mg/kg for 28 consecutive days...

INTRODUCTION Clerodendrum capitatum (Willd) Schumach. & Thonn (Lamiaceae) is used in African traditional medicine for the treatment of malaria, hypertension, obesity, jaundice and diabetes however there is lack of experimental data on its possible toxicity. This study investigated the acute and 28 days sub-chronic toxicity of C. capitatum in Wistar rats. METHODS In acute toxicity tests, a sin...

Abstraet--Surfactants are one of the major components (10-18%) of detergent and household cleaning products and are used in high volumes. Several are commonly found in natural waters and consequently, their impact on the environment has been, and continues to be, discussed in the U.S.A., Western Europe and Japan. The chronic and sublethal toxicities of commercially important surfactants to aqua...

Cerium dioxide nanoparticles (CeO2 NPs) are increasingly being used as a catalyst in the automotive industry. Consequently, increasing amounts of CeO2 NPs are expected to enter the environment where their fate in and potential impacts are unknown. In this paper we describe the fate and effects of CeO2 NPs of three different sizes (14, 20, and 29 nm) in aquatic toxicity tests. In each standard t...