METHODS. Immunofluorescence microscopy was used to identify molecular components of CLANs and quantitate CLAN formation in HTM cells plated on coverslips coated with various extracellular matrix (ECM) proteins (fibronectin, types I and IV collagen, and vitronectin), vascular cell adhesion molecule (VCAM)-1, or activating antibodies against 1, 3, or 2 1 integrins. These integrin antibodies were ...

subgraph. (a) x has to belong to a triangle, (b) x has to belong to a 2-clan of size at least 6, (c) x has to be connected to a vertex y such that the degree of y is at least 6, (d) x has to belong to a connected component whose

From a single pharmacy in Izmir opened by the founder of dynasty Süleyman Ferit to an industrial corporation whose fields activity include construction materials, pharmaceuticals, consumer goods, investment and real estate, story entrepreneurial success Eczacıbaşı family unfolded against backdrop turbulent political social life Ottoman Empire Turkey 20th century. The presented article examines ...

Purpose Increased intraocular pressure results from increased aqueous humor (AH) outflow resistance at the trabecular meshwork (TM) due to pathologic changes including the formation of cross-linked actin networks (CLANs). Transforming growth factor β2 (TGFβ2) is elevated in the AH and TM of primary open angle glaucoma (POAG) patients and induces POAG-associated TM changes, including CLANs. We d...

Diterpene resin acids, together with monoterpenes and sesquiterpenes, are the most prominent defence chemicals in conifers. These compounds belong to the large group of structurally diverse terpenoids formed by enzymes known as terpenoid synthases. CYPs (cytochrome P450-dependent mono-oxygenases) can further increase the structural diversity of these terpenoids. While most terpenoids are charac...