Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO, United States McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States Department of Neurological Surgery, Washington University Sc...

We read the publication on “Serum tissue factor (TF) as a biomarker for renal clear cell carcinoma”. Silva et al. noted that “TF appears to be a useful serum marker for the presence of clear cell RCC (1)”. Indeed, to conclude that TF is an important biomarker, there should be a complete evaluation on this diagnostic test. Sensitivity and specificity should be studied. Also, some confounding med...

Abstract Angiopoietin-1 (Angpt1) is a secreted protein that can promote angiogenesis and vascular stability in development certain disease states through activation of the Tie2 receptor. However, little known about its expression or function across brain tumor types. Surveying pediatric adult tumors we show Angpt1 upregulated glial tumors, including high-grade gliomas ependymomas, patterns corr...

introduction: metastatic lesions of the oral cavity are extremely rare, accounting for approximately 1% of all malignant oral tumors. the most common primary sources of metastatic tumors in the oral region are, from the most to the least common, the breast, lung, kidney, bone, and colon. renal cell carcinoma accounts for nearly 3% of all adult malignancies. it usually metastasizes to the lungs,...

E is a common type of pediatric brain tumors (≈10% of all central nervous system tumors in the pediatric age group), it is usually located in the infratentorial compartment and a third of the ependymomas are supratentorial. Of the supratentorial ependymomas, extraventricular ones are rare and usually located in close proximity to the ventricles (some still have connection to ventricle margin). ...