A mathematical approximation technique has been used for the analysis of pressure-volume and decay curves to see which of two concepts of the mechanical properties of the coats of the eye is the more valid. One concept—that the outer coats are nonlinear elastic—stems from the early work of Friedenwald* and is currently in use. The other concept—that the outer coats are nonlinear viscoelastic—st...

The optimal trade-off between offspring size and number can depend on details of the mode of reproduction or development. In marine organisms, broadcast spawning is widespread, and external coats are a common feature of spawned eggs. Egg jelly coats are thought to influence several aspects of fertilization and early development, including the size of the target for sperm, fertilization efficien...

Sperm limitation may be an important selective force influencing gamete traits such as egg size. The relatively inexpensive extracellular structures surrounding many marine invertebrate eggs might serve to enhance collision rates without the added cost of increasing the egg cell. However, despite decades of research, the effects of extracellular structures on fertilization have not been conclus...

1. Durán RM, Brotons DA, Argüelles IZ, Concepción PM. Temas de actualidad en cardiología pediátrica y cardiopatías congénitas. Rev Esp Cardiol. 2008;61 Supl 1:15-26. 2. Khambadkone S, Coats L, Taylor A, Boudjemline Y, Derrick G, Tsang V, et al. Percutaneous pulmonary valve implantation in humans: results in 59 consecutive patients. Circulation. 2005;112:1189-97. 3. Lurz P, Coats L, Khambadkone ...

PURPOSE To determine the prevalence, clinical characteristics and nature of subfoveal nodules in Coats' disease and the associated impact on the long-term visual outcome. METHODS Consecutive cases of Coats' disease with foveal exudation were retrospectively reviewed. The presence of a subfoveal nodule or macular fibrosis was recorded. Clinical characteristics, retinal imaging, and outcome wer...

A WHITE COAT. THE COUNTRY DOCTOR’S BLACK BAG. A STETHOSCOPE. A snake-entwined staff. The oath of Hippocrates. The clinical acumen of Osler and the compassionate service of Schweitzer. These are the symbols and personifications of our chosen profession. One symbol of medicine since antiquity has been the Aesculapian staff. A glance through this journal will uncover the staff in the American Medi...

To investigate the covariation of adult body condition and nestling growth, we weighed adult Brünnich’s Guillemots Uria lomvia rearing chicks at Coats Island, Nunavut, Canada, each year between 1988 and 2002. We estimated chick mass at 14 days for a sample of chicks reared in the same years. Adult mass and chick mass at 14 days were highly correlated, suggesting that, as feeding conditions dete...

BACKGROUND The exact pathogenetic mechanisms of Coats' disease remain unknown. In this report, we show two cases of Coats' disease that achieved a favorable prognosis with the combined treatment of intravitreal bevacizumab (IVB) injection prior to photocoagulation, although both initially resisted photocoagulation therapy. CASE PRESENTATIONS Case 1 was a 15-year-old boy with initial visual ac...

BACKGROUND Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats and those with black-colored coats, with the goal of identifying novel genes that could regulate horse coat color. RESULTS Genes encoding rib...

To determine the nature and cellular localization of amino acid transport in pea seeds, two cDNA clones belonging to the AAP family of H(+)/amino acid co-transporters (PsAAP1 and PsAAP2) were isolated from a cotyledon cDNA library of pea (Pisum sativum L.). Functional expression in the yeast amino acid uptake mutants 22Delta6AAL and 22Delta8AA showed that PsAAP1 mediates transport of neutral, a...