Besides the geometrical tortousity due to the extrasynaptic structures, macromolecular crowding and geometrical irregularities constituting the cleft composition at central excitatory synapses has a major and direct role in retarding the glutamate diffusion within the cleft space. However, the cleft composition may not only coarsely reduce the overall diffusivity of the glutamate but may also l...

Introduction: A cleft lip with or without a cleft palate is one of the major congenital anomalies observed in newborns. This study explored the risk factors for oral clefts in Gorgan, Northern Iran.  Materials and Methods: This hospital-based case-control study was performed in three hospitals in Gorgan, Northern Iran between April 2006 and December 2009. The case group contained 33 newborns...

cleft hand deformity is a rare congenital anomaly of the hand with an incidence rate about 1/90,000. it has two clinical types typical and atypical. in this paper we are representing ten cases of this anomaly admitted during seven years from 1992 in emam khomeini hospital. some of the patients especially those with typical cleft hand deformity achieved good functional results after surgical cor...

Introduction: Facial deformities and aesthetic and functional anomalies in children may be a cause of real distress in families. Problems faced by parents in coping with a child’s anomaly can be upsetting and lead parents to exhibit over-severe behavior. The present study was conducted in order to study the effect of happiness program on the happiness of the mothers of children with a cleft lip...

Background: Cleft lip and/or palate is the most common craniofacial congenital anomaly encountered by plastic surgeon. Both reconstruction and outcome assessment are challenging. This study aimed to assess of unilateral cleft repair in Surabaya CLP Center.Methods: All patients who underwent 2017 were included study. Those without complete photographs at minimally 52 weeks after surgery excluded...

Aim: Cleft lip and palate (CLP) patients have a greater predisposition to tooth malformation, which could affect pulp volume. The aim of this study is evaluate the dental volume central incisors in 3D images between individuals with without CLP. Materials Methods: This retrospective case-control single-centered was recruited January 2016 October 2022. Ninety-four who were followed Institute Ort...

Introduction: Cleft lip and palate is a congenital anomaly occurring in 3 in 1000 live birth. One the major concern in this patient is about cleft gap and its surgical problems. Several surgical and non-surgical procedures have been done to decrease this gap. They aimed to achieve the more esthetic results as well as feeding success. Nasoalveolar Molding (NAM) is a new method for reshaping nasa...

Objective To determine in individuals with unilateral cleft lip and palate the correlation between initial cleft size and dental anomalies, and the outcome of alveolar bone grafting. Methods A total of 67 consecutive patients with non-syndromic unilateral complete cleft lip and palate (UCLP) were included from the cleft lip and palate-craniofacial center, Uppsala University Hospital, Sweden. Al...

A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases -- 377 with cleft lip with or without cleft palate and 196 with cleft palate only -- and 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containing beverages in early pregnancy was recorded shortly after birth. Compared wit...