1. The fate in the rabbit of the following compounds has been investigated: benzohydrazide and its p-chloro, p-methyl and nand p-hydroxy derivatives; 1-acetyl-2-mand -p-hydroxybenxoylhydrazines and their anhydrides; 2-mand -phydroxyphenyl-5-methyl-1-oxa-3:4-diazoles. 2. Benzohydrazide, p-chlorobenzohydrazide and p-methylbenzohydrazide were lethal to rabbits in oral doses of just over 100 mg./kg...

An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C₁ or -C₂ side chain, has been developed. A key intermediate was the chiral, N-Boc-protected ketone (1R,2S,6S,7R)-4-azatricyclo[5.2.1.0²,⁶]decan-8-one, available from inexpensive endo-carbic anhydride in five steps and...

Environmental restoration is not simply a practical matter. The topic carries with it immense of metaphysical and aesthetic interest. In the same way that the science of ecology and cultural phenomenon of environmental politics are inseparable, restoration of the environment is inextricably tied to and informed by several areas of discourse: ecology, cultural ecology, human ecology, environment...

Subcellular fractions from the avocado pear ( Persea americana) catalyzed formation of p-chloroaniline from p-chloro-N-methylaniline. Fractions prepared by centrifugation of avocado homogenates at 20, 000g for 20 min formed p-chloroaniline (2900 +/- 500 pmol min-1 mg protein-1) with an NADPH-generating system. p-Chloroaniline formation required reduced pyridine nucleotide (NADPH was 6-7 times m...

1. We have compared the binding properties of several hexocyclium and sila-hexocyclium derivatives to muscarinic M1 receptors (in rat brain, human neuroblastoma (NB-OK 1) cells and calf superior cervical ganglia), rat heart M2 receptors, rat pancreas M3 receptors and M4 receptors in rat striatum, with their functional antimuscarinic properties in rabbit vas deferens (M1/M4-like), guinea-pig atr...

The anhydrous salts of 2-(1H-indol-3-yl)ethanamine (tryptamine) with isomeric (2,4-di-chloro-phen-oxy)acetic acid (2,4-D) and (3,5-di-chloro-phen-oxy)acetic (3,5-D), both C10H13N2 (+)·C8H5Cl2O3 (-) [(I) and (II), respectively], have been determined and their one-dimensional hydrogen-bonded polymeric structures are described. In the crystal of (I), the aminium H atoms are involved in three separ...

Metronidazole and niridazole combined with dehydroemetine in treatment of children with amoebic liver abscess. Metronidazole combined with dehydroemetine cured 13 of 15 children with amoebic liver abscess. An alternative combination of niridazole with dehydroemetine produced cure in 13 of 14 children. No relapses were observed. Electrocardiographic changes were noted in 2 of the first group and...

Whole cell recordings were performed on acutely dissociated neurons from the horizontal limb of the diagonal band of Broca (hDBB) from rats to elucidate the ionic mechanisms of action of neurotensin. Neurotensin caused a decrease in whole cell voltage-activated outward currents and failed to elicit a response when Ca2+ influx was blocked by changing the external solution to the one containing 0...

Nine monoand di-chloro-s-triazine (Procion) dyes (Table) have been tested for possible use as vital markers in rhesus monkeys (Macaca mulatta). Goland and Grand (Am J Phys Anthropol 29:201-218, 1968), Prescott, Mitchell, and Fahmy (Am J Phys Anthropol 29:219-224, 1968), and Seiton and Engel (Am J Anat 126: 373-391, 1969) have demonstrated that certain types of reactive dyes are preserved in dec...

An important characteristic of long-term potentiation (LTP) in the hippocampal CA1 region is that it is specific for those synapses which are active during the induction event. This input specificity is commonly attributed to the location and properties of the N-methyl-D-aspartate (NMDA) receptor channel. Experiments using strong high-frequency orthodromic activation have suggested that input-s...