Summary: Molecular Integrated Development Environment (MolIDE) is an integrated application designed to provide homology modeling tools and protocols under a uniform, user-friendly graphical interface. Its main purpose is to combine the most frequent modeling steps in a semi-automatic, interactive way, guiding the user from the target protein sequence to the final three-dimensional protein stru...

AIMS The aim of this work was to evaluate the agreement between temporomandibular joint click sound and MR diagnoses of different disk positions. METHODS One hundred ninety-four (N=194) patients seeking treatment for temporomandibular disorders at the TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy, underwent a bilateral magnetic resonance of the temporomandibular...

The biocompatibility of a triazole mimic of the DNA phosphodiester linkage in Escherichia coli has been evaluated. The requirement for selective pressure on the click-containing gene was probed via a plasmid containing click DNA backbone linkages in each strand of the gene encoding the fluorescent protein mCherry. The effect of proximity of the click linkers on their biocompatibility was also p...

Click trains were generated with first- and second-order statistics following Kaernbach and Demany [J. Acoust. Soc. Am. 104, 2298-2306 (1998)]. First-order intervals are between successive clicks, while second-order intervals are those between every other click. Click trains were generated with a repeating alternation of fixed and random intervals which produce a pitch at the reciprocal of the ...

It is important for search and pay-per-click engines to penetration test their click fraud detection systems, in order to find potential vulnerabilities and correct them before fraudsters can exploit them. In this paper, we describe: (1) some goals and desirable qualities of a click fraud penetration testing system, based on our experience, and (2) our experiences with the challenges of buildin...

Thanks to its low product-promotion cost and its efficiency, targeted online advertising has become very popular. Unfortunately, being profile-based, online advertising methods violate consumers’ privacy, which has engendered resistance to the ads. However, protecting privacy through anonymity seems to encourage click-fraud. In this paper, we define consumer’s privacy and present a privacy-pres...

Clickthrough data has been the subject of increasing popularity as an implicit indicator of user feedback. Previous analysis has suggested that user click behaviour is subject to a quality bias—that is, users click at different rank positions when viewing effective search results than when viewing less effective search results. Based on this observation, it should be possible to use click data ...

When a searcher submits a query Q and clicks on document R in the corresponding result set, we may plausibly interpret the click as a vote that Q is a description of R. We call the Q and R pairing a ‘click description’. Click descriptions thus derived from search engine logs can be accumulated into surrogate documents and used to boost retrieval effectiveness in a similar fashion to anchor text...