Effective and safe drug administration in neonates should be based on integrated knowledge on the evolving physiological characteristics of the infant who will receive the drug and the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. Consequently, clinical pharmacology in neonates is as dynamic and diverse as the neonates we admit to our units while covariates explaining the var...

Terbinafine hydrochloride is a white to off-white fine crystalline powder. It is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Each tablet contains: Active Ingredients: terbinafine hydrochloride (equivalent to 250 mg base) Inactive Ingredients: colloidal silicon dioxide, NF; hydroxypropyl methylcellulose, USP; magnesium stearate, NF; micro...

This book, written by Meyer and Gottlieb, professors of pharmacology at Vienna and Heidelberg, respectively, has been translated into English by Halsey, professor of pharmacology and clinical medicine at Tulane. It deals with " scientific drug therapy" and confines itself to that portion of pharmacology which should aid the physician in practising his profession. Medicinal substances are dealt ...

.........................................................................................8 INTRODUCTION................................................................................11 REVIEW OF THE LITERATURE...........................................................14 1. Epidemiology of poisonings……………………………………………………...14 2. Management of acute drug poisonings………………………………...………....15 3. Gast...

Studies were conducted in 30 patients with neoplastic diseases. Twelve patients received sisomicin intramuscularly at doses of 20 mg/m(2) and 40 mg/m(2). The mean peak serum concentration occurred at 1 h and was 2.5 mug/ml and 4.0 mug/ml, respectively. Ten patients received intravenous sisomicin at doses of 30 mg/m(2) during 30-min infusion. Mean peak serum level determined at 30 min was 5.1 mu...