This paper presents asynchronous switch between any two different local clock synchronous domains. The asynchronous switch will generate a slower clock from two local clock modules and moderate the high rated clock domain to slow down its clock frequency without stopping or pausing any clock of them throughout the data communication among them. The proposed design is implemented using the CMOS ...

Einstein's theory of general relativity is based on the premise that physical laws take same form in all coordinate systems. However, it still presumes a preferred decomposition total kinematic Hilbert space into local spaces. In this paper, we consider quantum gravity does not come with partitioning space. It pointed out that, such theory, dimension, signature, topology and geometry spacetime ...

Regulated expression of a core set of clock genes is the basis of circadian timekeeping in vertebrates, as in other organisms. Clock genes are defined as being necessary to generate normal circadian rhythms, near 24 h oscillations in biological processes. With the enlargement of the brain in vertebrates, control of circadian rhythms became centralized. In lower vertebrates, such as fishes, liza...

Digital systems commonly use a single global clock signal to synchronize the whole system. This is not always possible and it can be more advantageously to divide the system into separate clock domains, where each clock domain can operate with its own clock frequency. Communication between the different clock domains are not trivial and must be handled with care. Several schemes can be used dep...

We examined the transcriptional regulation of the clock-controlled arginine vasopressin gene in the suprachiasmatic nuclei (SCN). A core clock mechanism in mouse SCN appears to involve a transcriptional feedback loop in which CLOCK and BMAL1 are positive regulators and three mPeriod (mPer) genes are involved in negative feedback. We show that the RNA rhythm of each mPer gene is severely blunted...

In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulation with serum rapidly induced nuclear translocation, heterodimerization and Se...