High serum follicle stimulating hormone (FSH) values are consistent with ovarian failure. We studied the progress of 67 women aged under 35 years with oligomenorrhoea or secondary amenorrhoea in whom the serum FSH value was greater than 20 U/1. Twenty-four patients remained amenorrhoeic, but 17 ovulated and six conceived, two on two occasions. Coincident mean serum luteinising hormone (LH) conc...

CONTEXT Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2nd line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since letrozole is a drug for breast cancer, its use for the purpose of ovulation induction became controvers...

BACKGROUND Among women with unexplained infertility, 28% to 55% of patients with galactorrhea are normoprolactinemic. Bromocriptine, a common treatment for infertile women with hyperprolactinemia, has been used in the treatment of unexplained subfertility in women with galactorrhea and normal prolactin; however, its effectiveness and safety profile have never been determined. OBJECTIVE The ai...

background: for more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. the aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome.   methods: in this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized i...

We describe the case of an acromegalic woman with primary infertility who was treated with clomiphene, and subsequently developed pituitary apoplexy.

1. Metformin is not efficient enough in order to regulate menstrual cycles. 2.Metformin is not efficient enough in order to treat hyperandrogenism. 3. Metformin should not be used as a first-line treatment in order to treat infertility. Clomiphene citrate (CC) is the reference treatment. 4. Metformin in addition to CC is not recommended as a second line treatment, after the failure of CC alone....

background: unexplained infertility is still a challenging issue as to its causes, appropriate management and treatment. evidence implicates early embryopathy or implantation failure as likely causes. objective: this study aims to investigate the effect of local endometrial injury on pregnancy rate in selected unexplained infertile patients. materials and methods: this was a randomized clinical...

OBJECTIVE To determine the day of ovulation by the salivary ferning test in clomiphene citrate-treated women. DESIGN A descriptive study. SETTING Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. SUBJECT Seventy-five infertile women with regular menstrual cycles. MATERIAL AND METHOD Infertile women were given 100 mg of clomiphene ...

BACKGROUND Findings from the few epidemiological studies that have investigated thyroid cancer risk after fertility drugs have been inconclusive. Using data from the largest cohort of infertile women to date, we examined the effects of fertility drugs on thyroid cancer risk. METHODS A cohort of 54 362 women with infertility problems referred to Danish fertility clinics in the period 1963-1998...