Dear Editor: Clonidine is used to manage a variety of psychiatric symptoms in addition to general medical conditions such as hypertension and pain. We report a case of auditory hallucinations in the context of clonidine use. Case report. A 53-year-old African-American man was in a motor vehicle accident that resulted in multiple orthopedic surgeries and an extensive rehabilitation process. He h...

BACKGROUND AND AIM Postoperative nausea vomiting (PONV) is the most common symptom in patients post thyroidectomy. Literature search shows conflicting results regarding use of clonidine in PONV prophylaxis. We undertook this randomized controlled double blind trial to compare the efficacy of clonidine with dexamethasone versus ondansetron with dexamethasone for PONV prophylaxis in these patient...

Preemptive analgesia aims to prevent the sensitization of central nervous system, hence the development of pathologic pain after tissular injury. The aim of the study was to assess the effect of preincisional clonidine treatment on analgesic consumption and hemodynamic stability compared to clonidine administered at the end of the operation and control group. Ninety-one patients undergoing elec...

BACKGROUND Morphine and clonidine show synergy or antagonism inhibiting gastrointestinal transit depending on their proportion and level of effect. Their interaction during morphine tolerance and intestinal inflammation were assessed. METHODS Gastrointestinal transit in mice was evaluated with charcoal and antitransit effects expressed as percent mean values +/- SEM. Tolerance was induced wit...

The depressor and sympathoinhibitory effect of the imidazoline drug clonidine is reported to be associated with functional states of the central glutamate receptors. The rostral ventrolateral medulla (RVLM) has been recognized as a specific target area for mediating the central depressor mechanism of clonidine. The objective of this study was to determine the role of the glutamate receptor subt...

Schedule-controlled responding was maintained under multiple fixed-interval, fixed-ratio schedules in pigeons and single fixed-ratio schedules in mice. In pigeons, clonidine, an alpha 2-receptor agonist, produced dose-related decreases in responding under both fixed-interval and fixed-ratio schedules; fixed-interval responding was decreased at a lower dose than fixed-ratio responding. Low to in...

The effects of infusion of clonidine, an a2-adrenergic agonist, on plasma insulin-like growth factor-I (IGF-I) concentrations were investigated with a single growth hormone (GH) injection in pigs. Four barrows were subjected to four treatments: saline infusion with a vehicle injection, clonidine infusion (0.5 nmol/kg/min for 8 h) with a vehicle injection, saline infusion with a bovine GH (bGH:1...

OBJECTIVES Premedication with clonidine has been found to reduce the bleeding during endoscopic sinus surgery (ESS), therefore lowering the risk of surgical complications. Premedication is an essential part of pre-surgical care and can potentially affect magnitude of systemic stress response to a surgical procedure. The aim of this study was to compare the efficacy of premedication with clonidi...

PURPOSE To investigate the influence of low dose clonidine premedication on perioperative glucose homeostasis. METHODS Sixteen patients undergoing abdominal hysterectomy for benign uterine myoma were randomly assigned to receive either iv clonidine (1 microg x kg(-1)) 30 min before induction of general anesthesia (clonidine, n=8) or saline (control, n=8). Plasma concentrations of glucose, ins...

We examined the effects of clonidine injected unilaterally into the rostral ventrolateral medulla (RVLM) of conscious, unrestrained rats. We also examined whether the local alpha(2)-adrenoceptor mechanism contributed to the action of clonidine injected into the RVLM. Injection of clonidine but not vehicle solution significantly decreased the mean arterial pressure (MAP), heart rate (HR), and re...