Broth cultures of hemolytic streptococci derived from patients are capable of rapidly liquefying normal human fibrin clot. The active fibrinolytic principle is also contained in sterile, cell-free filtrates of broth cultures. The degree of activity of filtrates parallels the activity of whole broth cultures sufficiently closely to indicate that large amounts of the fibrinolytic substance are fr...

By J. PHILIP SAVITSKY, M.D. C HANGES in platelet adhesivemiess have been noted during the course of many different clinical conditions.t4 Imicreased platelet adhesiveness has been correlated by some investigators with a predisposition to thromboembolic phemiomena and vascular disease,2 but other work has not confirmed this suiggestion.3 It has been show’mi that there is a very close relation be...

BACKGROUND Systemic embolism is a serious and sometime fatal complication of rheumatic MS. OBJECTIVE We assessed the predictive power of D-Dimer level to predict occurrence of left atrial (LA) thrombi in patients with rheumatic mitral stenosis (MS). METHODS D-dimer levels were analyzed for 24 patients with rheumatic MS with LA clot and 22 patients with rheumatic MS with no LA clot undergoin...

The impairment of formation and maintenance of a formed fibrin clot contributes to the prolonged bleeding and high incidence of rebleeding in upper gastrointestinal haemorrhage. To investigate the basis for the use of drug therapy in gastric bleeding, this study used thrombelastography to determine the effects of pharmacological manipulation of gastric juice on coagulation and fibrinolysis. The...

OBJECTIVES Primary Sjögren's syndrome (pSS) shares clinical features and pathogenetic mechanisms with systemic lupus erythematosus (SLE). SLE is associated with an increased thromboembolic risk; however, it is unclear whether pSS patients are susceptible to thromboembolic diseases. In this study, we examined ex vivo blood clot formation (clot strength, rates of clot formation and lysis) in pSS ...

Despite the life-preserving function blood clotting serves in the body, inadequate or excessive blood clot stiffness has been associated with life-threatening diseases such as stroke, hemorrhage, and heart attack. The relationship between blood clot stiffness and vascular diseases underscores the importance of quantifying the magnitude and kinetics of blood's transformation from a fluid to a vi...

Hemostasis depends largely on the conversion of fibrinogen to fibrin, catalyzed by the enzyme thrombin. In recent years, there has been considerable advance of knowledge of the formation of thrombin from its various precursors. However, a comparatively small amount of effort has been directed toward studies of the physical nature of the fibrin clot as a possible guide in the better understandin...

Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an in vitro reaction-diffusion experimental model of blood clot formation and dissolution. Clotting was activated by a surface with immobilize...