OBJECTIVES Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 years on ART. DESIGN We describe longitudinal analyses of plasma from 13 HIV ...

background: cytomegalovirus (cmv) infection is associated with significant maternal and fetal consequences. the aim of pre­sent study was to determine the current prenatal cmv seroprevalence in eastern azerbaijan and evaluate the routine labora­tory diagnostic techniques of anti-cmv immunoglobulin m (igm) and immunoglobulin g (igg). methods: during the present prospective cross-sectional study,...

introduction: cytomegalovirus (cytome-galovirus: cmv) infection is a common cause of morbidity and mortality in patients who are the candidate for liver transplant. serological monitoring of individuals rece-iving and giving the liver transplant is necessary for prevention, early diagnosis and treatment strategies and reducing the prevalence of infection. the aim of this study was to assess the...

Congenital cytomegalovirus (CMV) infection is a leading cause of hearing, cognitive, and motor disability in children for which medical science has yet to provide prevention or cure. Although vaccines aimed at prevention of congenital infection are being developed, there are significant challenges to be overcome and it could easily be a decade or longer before a CMV vaccine is licensed for prev...

Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcome...

Transfusion-transmitted cytomegalovirus (TT-CMV) infection can lead to significant morbidity and mortality in CMV-negative (CMV-N) hematopoietic progenitor cell (HPC) transplant patients. In 1995, Bowden and colleagues demonstrated the efficacy of leukoreduced components to reduce TT-CMV in most high-risk populations, although there remained safety concerns in CMV-N allogeneic HPC transplant re...

We aimed to compare the diagnostic value of various detection methods for cytomegalovirus (CMV) infection, to investigate the genetic mechanism associated with CMV infection in pregnant women, and to analyze the risk of sequelae development in fetuses with CMV infection. A total of 300 participants who had the same immunosuppressive regimen and received preemptive therapy for CMV infection were...

BACKGROUND Cytomegalovirus (CMV) infection induces upregulation of tissue factor and loss of anticoagulants, including thrombomodulin, prostacyclin, and tissue plasminogen activator. CMV infection may thereby increase the procoagulant properties of coronary artery plaques. This prospective study investigated the effect of previous CMV infection on the early hazard of coronary stent placement. ...

Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. This can be seen in the recipients after reconstitution with donor lymphocytes. We evaluated the composition of lymphocytes at hematologic recovery i...

OBJECTIVE Breast milk is the most important nutrient to all newborn babies. If the mother's milk production is insufficient, it is important to provide donor breast milk without reduction of its immunologic and antimicrobial properties. Early use of breast milk to preterm infants has shown a reduced incidence of necrotising enterocolitis, a faster tolerance of enteral feeding, and a reduced nee...