Human cytomegalovirus has a complex double-stranded DNA genome of approximately 240,000 bp that contains approximately 150 ORFs likely to encode proteins, most of whose functions are not well understood. We have used an infectious bacterial artificial chromosome to introduce 413 defined insertion and substitution mutations into the human cytomegalovirus AD169 genome by random and site-directed ...

In 2008-2018, 89 pregnant women registered at the Beaumonde Clinic were observed with only cytomegalovirus activity. Laboratory tests for performed 4 times in total, and ultrasound examination was 3 during pregnancy. The results distributed as follows: (1) We could have assumed high probability that we had reinfection processes not a primary infection. (2) During examinations, no significant or...

Diabetic and Non-Diabetic Patients Hospitalized with Acute Bacterial Skin and Skin Structure Infection Timothy Jenkins, MD; Bryan Knepper, MPH, MSc; S. Jason Moore, PhD, PA; Bruce Mccollister, MD; Carla Saveli, MD; Sean Pawlowski, MD; Daniel Perlman, MD; William Burman, MD; Medicine/Infectious Diseases, Denver Health Medical Center, Denver, CO; Denver Health Medical Center, Denver, CO; Vail Val...

Cytomegalovirus (CMV) and Pneumocystis jirovecii fungus are the main opportunistic microorganisms that affect transplanted individuals. Immunosuppressive drugs administered to prevent organ rejection leave immune system vulnerable these infections. The present report is about a kidney patient using immunosuppressants who was diagnosed with cytomegalovirus pneumocystosis requiring admission inte...

and Non-Injection Drug Users Hospitalized with Acute Bacterial Skin and Skin Structure Infection Timothy Jenkins, MD; Bryan Knepper, MPH, MSc; S. Jason Moore, PhD, PA; Bruce Mccollister, MD; Carla Saveli, MD; Sean Pawlowski, MD; Daniel Perlman, MD; William Burman, MD; Medicine/Infectious Diseases, Denver Health Medical Center, Denver, CO; Denver Health Medical Center, Denver, CO; Vail Valley Me...

Cytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15-49 basing on existing serum bank. Age dependent incidence, the rates of congenital infection and sequelae were modelled from sero-p...

We assessed the value of the cytomegalovirus (CMV) antigenemia assay for diagnosing primary CMV infection in adults. The CMV antigenemia assay was performed for 40 patients admitted to our unit over a 2-year period with unexplained fever and suspected primary CMV infection. Nine of the 10 patients with primary CMV infection had positive CMV antigenemia assays, and the results were available wit...

Cytomegalovirus infection (CMVI) is an actual problem of perinatology, as it is one of the most frequent congenital infections and occurs in 0.2% to 2.5% of newborns [1-4]. Congenital CMVI can occur both in severe form, in which a lethal outcome is possible, and in the forms of low-symptom and asymptomatic variants [2,4-7]. Low-symptom and asymptomatic forms often occur under the “masks” of var...

Massive splenic infarction (SI) is an extremely rare disease in childhood, the genesis of which not always clear. Most often children, SI develops against background oncohematological (in particular, myeloid leukemia), hematological (sickle cell anemia) and infectious (malaria, mononucleosis, cytomegalovirus infection) diseases small size. Two own observations are presented, unique absence a cl...