Knowledge of drug-drug interactions is crucial to HIV therapeutics. Recent reports in this area include reduced atazanavir exposure with coadministration of omeprazole or rifampin; increased hepatic toxicity with coadministration of saquinavir and rifampin; reduced buprenorphine exposure with concurrent efavirenz administration; absence of clinically significant interactions of depomedroxyproge...

Metformin is 1,1-dimethylbiguanide hydrochloride, the first-line therapy for type 2 diabetes. Additionally, several studies focused on role of metformin in antioxidant activities treatment hepatic disorders. The experimentally
 
 -based result valproic acid's liver injury, a front-line medicine epilepsy, attracted lot interest. As result, effect acid-induced redox disturbances rat tis...

OBJECTIVE To determine the potential for pharmacokinetic interaction between nefazodone (NFZ), and desipramine (DMI). METHOD A single center, open-label, multiple-dose, parallel-group pharmacokinetic trial conducted in 28 healthy male and female subjects. Group A received DMI 50 mg/day for 2 days followed by DMI 75 mg/day for the next 17 days. On Days 10-14, subjects also received 100 mg NFZ ...