Concise guidelines are presented that relate abnormalities of coagulation, whether the result of the administration of drugs or that of pathological processes, to the consequent haemorrhagic risks associated with neuraxial and peripheral nerve blocks. The advice presented is based on published guidelines and on the known properties of anticoagulant drugs. Four separate Tables address risks asso...

In 1975, Hougie et all reported a moderate bleeding disorder transmitted in an autosomally dominant fashion in five members of a single family. This disorder was attributed to the deficiency of a previous unrecognized coagulation factor, Passovoy factor. The proband in this report was described as a 29-year-old woman who, along with her brother, was said to have familial Mediterranean fever. A ...

were found to have evidence of a generalized hemostatic disorder. These patients could be divided into three groups. The first group consisted of three patients with increased fibrinogen catabolism without clinical or laboratory evidence of intravascular coagulation. The second group of five patients had laboratory evidence of intravascular coagulation without clinically evident bleeding or thr...

Immune activation has been recognized as an important component of the pathogenesis of HIV infection since the first recognition of cases of AIDS in the early 1980s. Early in the AIDS epidemic, patients with HIV infection were noted to have elevated levels of serum immunoglobulins. CD38 expression on CD4+ T cells was shown to be an independent predictor of survival in 1999. The characterization...

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Despite the large number of the outstanding researches, pathogenesis of osteonecrosis remains unknown. During the last decades the hypothesis that increased intravascular coagulation may be the pathogenetic mechanism which leads to osteonecrosis is gaining constantly support. Both primary factors of hyper-coagulability, such as resistance to activated protein C, protein C and protein S deficien...

Fifty-one men with atherosclerotic intermittent claudication and haemorheological abnormalities completed a double-blind, one-year randomised trial of Ticlopidine (500 mg/day), a new antiplatelet agent. Ticlopidine caused significant inhibition of platelet aggregation but did not fully correct abnormalities of coagulation, viscosity, and fibrinolysis. There was no significant improvement in wal...

INTRODUCTION Bleeding is one of the most feared risks from a renal biopsy. To determine this risk, a clotting screen is performed prior to the biopsy to identify any coagulation abnormalities. In addition, concerns exist with respect to bleeding from platelet dysfunction and the special cases of paraprotenemia. METHOD Literature search of all the relevant articles in relation to bleeding risk...

Non-cirrhotic portal hypertension (NCPH) is a poorly understood condition attributed to various causes in the absence of liver cirrhosis. One important and rare conditions leading NCPH myeloproliferative neoplasms blood coagulation abnormalities, which infiltrate cells stasis raised sinusoidal pressure. We present case 40-year-old male who presented our emergency department with complaints hema...