Every year in Germany nearly 3000 cases of child abuse were reported. When children are presented at emergency units with suspicious injuries and bruises a detailed documentation an evaluation is necessary after emergency treatment. As differential diagnosis inherited or acquired bleeding disorders should be excluded. In addition to a detailed evaluation of personal and family history and a phy...

Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic or supportive management. In recent years, n...

The studies on the morphology of lesions produced and the blood coagulation disturbances after Russell viper envenomation were studied in guinea pigs. The study showed very little morphological changes but the coagulation studies revealed disturbances in coagulation mechanism. The exact pathological process operating in Russell viper emvenomation needs further studies including the histochemica...

BACKGROUND Recombinant activated factor VII (factor VIIa) is a prohemostatic agent that can be used for patients with complicated coagulation disorders. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients with a preexistent normal coagulation system but who experience serious bleeding, for example, after major surgery or trauma. DATA SOURCE...

Introduction: Kidney dysfunction, coagulopathy disorders, and lung involvement are the most common disorders caused by COVID-19 virus. Objectives: This study aimed to investigate correlation of severity with kidney dysfunction in patients. Patients Methods: descriptive-analytical was conducted on 97 patients referred Imam Reza hospital Kermanshah from December 2020 June 2021. Lung severity, fun...

The hemostatic balance is the result of an equilibrium between procoagulant and anticoagulant factors that interact with each other to ensure hemostasis at sites of vascular injury. Abnormalities of hemostatic factors due to defects in the corresponding genes can result in a tendency to hemorrhage or thrombosis. In the last few decades, the progressive identification of the mechanisms underlyin...

PURPOSE Coagulopathy may be a serious complicating or contributing factor to postpartum hemorrhage (PPH), and should be promptly recognized to ensure proper bleeding management. This study aims to evaluate the approaches of obstetrician-gynecologists worldwide towards assessing massive PPH caused by underlying bleeding disorders. METHODS A quantitative survey was completed by 302 obstetrician...

conclusions in the current study, the clinical and paraclinical signs of aflp were mostly - liver, coagulation, kidney, and hypoglycemia disorders. considering that patients mostly refer in three phases of clinical, laboratory, and complications, it is essential to evaluate the suspected ones who present clinical symptoms especially nausea, vomiting and abdominal pain. patients and methods this...

Activated partial thromboplastin time (aPTT) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These th...

Introduction Recent evidence suggests low-flow extracorporeal CO2 removal (ECCO2-R) systems as safe and promising adjunctive therapy to avoid endotracheal intubation and the related negative consequences in subjects with severe hypercapnic respiratory failure [1]. In high-flow extracorporeal membrane oxygenation systems heterogeneous coagulation disorders are a well-known complication. However,...