A study was conducted to evaluate the usefulness of GFR to assess the renal involvement in hypertension. GFR was assessed using the conventional blood urea and serum creatinine values and the eGFR is calculated based on serum creatinine by using the MDRD formula and Cockcroft – Gault formula. The values obtained were compared with serum Cystatin C and Cystatin based eGFR. It was observed that e...

This paper compares three methods for estimating renal function, as tested in rats. Acute renal failure (ARF) was induced via a 60-min bilateral renal artery clamp in 8 Sprague-Dawley rats and renal function was monitored for 1 week post-surgery. A two-compartment model was developed for estimating glomerular filtration via a bolus injection of a radio-labelled inulin tracer, and was compared w...

The aim was to evaluate performance of Cockcroft Gault (CG), modification of diet in renal disease (MDRD) formula in the prediction of glomerular filtration rate (GFR) as compared to 51Cr-EDTA GFR (isotope GFR) in diabetic chronic kidney disease (dCKD) and their relation with calcium and iron metabolism parameters. One hundred ambulatory patients with diabetes without nephrotic syndrome, renal ...

OBJECTIVES This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS Documented toxicity and creatinine clearance (calculated by the Cockcroft-Gault for...

Accurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration), and 24-hour urine collections for...

BACKGROUND Serum creatinine concentration is an inadequate screening test for chronic kidney disease, especially in elderly patients. We hypothesized that laboratory reporting of estimated glomerular filtration rate (GFR) accompanied with an educational intervention would improve recognition of chronic kidney disease (CKD). METHODS We conducted a before-and-after study at an outpatient family...

OBJECTIVE The best method to estimate glomerular filtration rate (GFR) in diabetic patients is still largely debated. We compared the performance of creatinine-based formulas in a European diabetic population. RESEARCH DESIGN AND METHODS We compared the performance of Cockcroft and Gault, simplified Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology (CKD-EPI...

We present a case of a hypersensitised end stage renal disease patient with impossibility of peritoneal dialysis and exhaustion of vascular access for haemodialysis, who presented a positive cross-match to her potential living related donors. A desensitisation protocol was applied and a renal transplant was successfully performed with the kidney from the living donor. The protocol was based on ...