background: fatigue, a major cause of disability in individuals with multiple sclerosis (ms), is associated with reduced quality of life. the aim of this study was to evaluate the reliability and reproducibility of the persian version of modified fatigue impact scale (mfis) in iranian patients with ms. methods: this study included 15 subjects with clinically definite ms, 15 hospitalized patient...

BACKGROUND Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991 and 2011, with identical study design and methods in each decade. METHODS Baseline data from the Cognitive Function and Ageing Studies in populations aged 65 years or old...

OBJECTIVES To assess the relationship of disability (activities of daily living (ADL) and instrumental ADL (IADL)), self-rated health (SRH), and 6-year mortality with co-existing impairments in vision (self-rated), hearing (self-rated) and/or cognition (Short Portable Mental Status Questionnaire) in older adults. METHODS The study sample was comprised of 3871 participants from the North Carol...

Despite the comorbidity between motor difficulties and certain disabilities, limited research has examined links between early motor, cognitive, and social skills in preschool-aged children with developmental disabilities. The present study examined the relative contributions of gross motor and fine motor skills to the prediction of improvements in children's cognitive and social skills among 2...

BACKGROUND Associations between vascular risk factors and late-life depression are controversial. AIMS To investigate the association between measures of vascular disease/risk and depression and confounding and effect modification by APOE genotype and cognitive function. METHOD In a Korean community population aged 65+ (n=732), diagnosis of depression (Geriatric Mental State Schedule) and i...

abstract   background: low back pain (lbp) is still a medical problem in 21 st century. having back pain and being disabled by it are not the same thing. it is common to come across with patients who have simple back pain but surprisingly totally disabled and vice versa. in clinical practice, it is important to have a proper evaluation of disability and making a clear distinction between pain a...

Alzheimer's disease (AD) progresses from a preclinical period, through a middle phase of cognitive deterioration, to a late, profound state. The temporal progression of disability can be modeled with a horologic (time-based) function using "time-index" (TI) intervals (day- or year-units) to quantify an individual's disability across multiple cognitive and functional domains relative to a refere...

BACKGROUND The challenges of today's society call for more knowledge about how to maintain all aspects of cognitive health, such as speed/attention, memory/learning, visuospatial ability, language, executive capacity and social cognition during the life course. MAIN TEXT Medical advances have improved treatments of numerous diseases, but the cognitive implications have not been sufficiently a...