Cognitive flexibility is affected by stress. The cold pressor test is a known adrenergic stressor that impairs memory, but the effect on cognitive flexibility is unknown. Sixteen subjects were given cognitive flexibility and memory tasks with and without one hand immersed in cold water. Memory was impaired in the cold pressor condition but there was no effect on cognitive flexibility. The lack ...

objective: lc/na system is activator of hypothalamic–pituitar–adrenal (hpa) axis and cold stress triggers an equally robust increase in plasma na. increased lhrh content probably due to absence or decrease of ne release from the lc and positive feedback action of e2 on lh secretion show that in late proestrous phase na, lh and e2 have a strong link. this study was conducted to evaluate the effe...

BACKGROUND Memantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress. METHODS Male rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (...

Oxidative stress causes cell death and induces many kinds of disease, including liver disease. Nitroxides are known to react catalytically with free radicals. In this study, the cell protective activities of nitroxides were compared with those of other antioxidants. Nitroxides showed much greater inhibition of hydrogen peroxide-induced cell death than other antioxidants in a hepatic cell line a...

Introduction:  Plants are a rich source of phenolic compounds that as natural antioxidants prevent oxidative stress and are very good for health. Ziziphora clinopodioides belongs to Lamiaceae family and its aerial parts are used in pharmaceutical and food industries. It is effective in the treatment of heart disorders, cold, depression, diarrhea, coughing, migraine and...

BACKGROUND Oxidative stress is known to play a role in the pathophysiology of metabolic syndrome and its components. Racial differences may exist in the level of markers of oxidative stress and antioxidants in patients with metabolic syndrome. AIM The aim of this study was to determine the oxidative stress and antioxidants status in subjects with metabolic syndrome in Sokoto, North-Western Ni...

Oxidants are highly unstable molecules that attack every chemical substance they come into contact. Oxidants modify the macromolecules both structurally and functionally. Body has defense mechanisms against oxidants in the form of both enzymatic and non-enzymatic antioxidants. Reactive oxygen species (ROS) are a group of oxidants formed during oxygen metabolism. ROS appears to be involved in th...

Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical jou...

Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading to neuro-degeneration. Neural cells suffer fun...