Understanding the protein-to-protein interactions at the subcellular level, as well as other organic molecules, is crucial to explain cellular functions and to elucidate disease mechanisms. These interactions can be captured visually by overlapping the fluorescent microscopic images of two proteins tagged with fluorescent labeling agents that react to green and red wavelengths respectively. Int...

Recent results suggest that neurons that contain multiple neurotransmitters may make synaptic connections with different target neurons that are mediated by only a subset of their transmitter complement.

Vitiligo and Lichen Planus, two common dermatologic disorders, are expected to coexist. This leads to diverse theories regarding their immunopathogenesis linkage. In this case, we report a twenty-year-old man suffering from simultaneous lichen planus and vitiligo which were both generalized at the time of observation and also concomitant throughout their entire course of progression. Lichen Pla...

Long noncoding RNAs (lncRNAs) are increasingly recognized as involved in human physiology and disease. Antisense lncRNAs ubiquitous the genome have many mechanisms of action proposed, but single-cell single-molecule information that is needed to support or refute these lacking. Although single molecule RNA-Fluorescent Situ Hybridization (RNA-FISH) a method sometimes used investigate lncRNAs, co...

The spatial relationship, or degree of colocalization, between two or more types of molecules in live cells is commonly detected using fluorescence microscopy. This spatial distribution can be used to estimate the interaction between fluorescently labelled molecules. These interactions are usually quantified by analysing the correlation and/or the overlap between images, using the Pearson's and...