نتایج جستجو برای: colon cancer cells
تعداد نتایج: 2121957 فیلتر نتایج به سال:
Background: In advanced stages, Colorectal cancer remains often refractory to classic therapies. In consequence, search for new therapeutic modalities with minimal toxicity is of particular interest in colon cancer management. In this regard, powerful growth-inhibitory effect has been shown for fish-oil derived Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) against cancer cells. In ...
In a previous study, the suppressor of IKBKE 1 expression level was confirmed to be higher in vincristine (VCR)-resistant HCT-8 (HCT-8/V) colon cancer cells than in non-VCR-resistant HCT-8 cells. In the current study, IKBKE 1 expression in VCR-resistant colon cancer cells was investigated further. HCT-8 and HCT-8/V human colon cancer cells were used, and polymerase chain reaction (PCR) primers ...
Nanoparticle Drug Delivery The encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite loaded with galunisertib are functionalized an anti-L1-CAM antibody that targets metastatic colon cells. These then encapsulated a gastro-resista...
The present study demonstrates the efficacy of utilizing TLR9 (toll-like receptor 9) agonism as a potential therapy for colon cancer. We examined the effects of two types of TLR9 agonists: a traditional CpG oligonucleotide and a novel immunomodulatory oligonucleotide in models of colon cancer, both alone and in combination with conventional cancer therapies. Because the tumor suppressor p53 is ...
Colorectal cancer (CRC) is one of the leading causes of cancer-associated mortality worldwide. There is increasing evidence that microRNAs (miRNAs) are involved in development and progression of colorectal carcinoma. miR-145 is a tumor suppressor and has been confirmed as a negative regulator of colorectal cancer. Although multiple target genes have been identified for miR-145, the molecular me...
in western countries there is a growing incidence in obesity, inflammatory bowel disease (ibd) and colorectal cancer (crc), which places an increasingly important burden on the health care system. in the current decade, changes in intestinal microflora (i.e., dysbiosis) are likely the result of environment factors such as food, lifestyle, and medications which have been shown in obesity and ibd...
b a c k g r o u n d & aim: it is very helpful to classify and predict the clinical category of a sample based on its gene expression profile. this study was conducted to predict tissues of colorectal adenoma, adenocarcinoma, and paired normal in colon based on microarray data using nearest shrunken centroid method. methods & materials: in this study, the co...
The chemoresistance of colon cancer cells limits the efficacy of chemotherapy. miR-409-3p has been shown to be downregulated in various types of cancer. In the present study, we examined the role of miR-409-3p in colon cancer as well as the effects of miR‑409-3p on the sensitivity of colon cancer cells to oxaliplatin. The expression of miR-409 was significantly downregulated in the human colon ...
BACKGROUND Tumor metastasis is an essential cause of the poor prognosis of colon cancer. DC-SIGNR is a C-type lectin that is frequently found on human liver sinusoidal endothelial cells. LSECtin, which is a homologue of DC-SIGNR, has been demonstrated to participate in colon cancer liver metastasis. Due to the similarities in the expression pattern and structure of the two proteins, we speculat...
Adiponectin is secreted by adipocytes and is a key hormone responsible for insulin sensitization. Recent studies have shown that plasma adiponectin is decreased in patients with breast, endometrial and gastric cancer. However, the effect of adiponectin on colorectal carcinogenesis is controversial. It is now well known that the adiponectin receptor exists in two isoforms, adiponectin receptor 1...
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