The present study describes the preliminary evaluation of the cytotoxicity from Gleditsiae Semen extracts. G. Semen was extracted with methanol, ethanol, and acetone, and then cytotoxic effect of these extracts was measured by the MTT reduction assay and phasecontrast microscopy on the HT-29 human colon carcinoma cells. Among these extracts, methanol extract showed the highest cytotoxic activit...

BACKGROUND Fascin is an actin-bundling protein that is absent from most normal epithelia yet is upregulated in multiple forms of human carcinoma, where its expression correlates clinically with a poor prognosis. How fascin-1 transcription is activated in carcinoma cells is largely unknown, although the hypothesis of regulation by beta-catenin signaling has received attention. The question is im...

Development of normal colon epithelial cells proceeds through a systematic differentiation of cells that emerge from stem cells within the base of colon crypts. Genetic mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon adenoma and carcinoma formation by enhancing colonocyte proliferation and impairing differentiation. We currently have a limited understanding of ...

adenocarcinomas. Adenosquamous carcinomas with consisting of both glandular and squamous histologic components are a rare malignancy of the colon and rectum. This tumor type was originally described by Herheimer in 1907. Subsequent reports of adenosquamous carcinomas of the rectum and/or colon are limited as the estimated incidence of adenosquamous carcinomas of the colon and rectum is approxim...

As the prevalence of gastric carcinoma decreases in Japan, the prevalence of colon cancer has been increasing. Examination of the screening practices for colon cancer in the United States can offer insight into practices that may be useful in Japan. This paper will review the epidemiology and risk factors for colon cancer, the genetics of colon cancer, prevention issues, screening modalities, a...