The Notch pathway contributes to self-renewal of tumor-initiating cell and inhibition of normal colonic epithelial cell differentiation. Deregulated expression of Notch1 and Jagged1 is observed in colorectal cancer. Hairy/enhancer of split (HES) family, the most characterized targets of Notch, involved in the development of many cancers. In this study, we explored the role of Hes1 in the tumori...

Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer anti-inflammatory properties. This study aimed to investigate the therapeutic effect of chrysin combined 5-fluorouracil (5-FU) treatment mice colorectal cancer (CRC). Moreover, effects these two compounds on expression β-catenin inducible nitric oxide synthase (iNOS) were investigated. The CRC was induce...

Abstract Background PD-1 checkpoint inhibitors are novel therapeutic agents in colorectal cancer (CRC). Immunohistochemical staining for CD274 assessment is standardised upper GI cancer, but not CRC. Methods Methodologies of relevant studies were scrutinized and meta-analysis survival CD274/PDCD1 performed. Furthermore, anti-PD-1 therapy clinical trial results CRC assessed with particular empha...

Colorectal cancer (CRC) is one of the most common malignancies globally, and morbidity mortality rates associated with it are among highest around world. Not even great advances in colorectal diagnosis treatment technologies have been able to increase 5-year survival rate this disease. Recidivation metastasis main causes death CRC, although underlying mechanism remains unknown. Long non-coding ...

Background: Colorectal cancer (CRC) is currently the third leading cause for cancer-related mortality. Cancer stem cells have been implicated in colorectal tumor growth, but their specific role biology, including metastasis, still uncertain. Methods: Increased expression of L1CAM, CXCR4 and NODAL was identified section patients with CRC patients-derived-organoids (PDOs). The evaluated using qua...

Colorectal cancer (CRC) is one of the most frequent human malignant neoplasms. CRC has an estimated incidence of more than 1,000,000 new cases annually worldwide. Approximately one out of three people who develop CRC dies from the disease. Furthermore, CRC often affects inhabitants of industrialized countries in comparison to less developed countries. Several markers of colon cancer, including ...

Ulcerative colitis (UC) and Crohn’s disease (CD) are the two common forms of inflammatory bowel disease (IBD). They share similar clinical and demographic features as well as harbor key differences in tissue damage and prognosis. Previous studies indicated that they contributed to the increased rick to Colorectal cancer (CRC). However, whether UC and CD share inflammatory signatures still remai...

As a standard way for prevention and early detection of colorectal cancer (CRC), colonoscopy has been used for CRC screening in the United States for more than one decade. An article entitled "Assessing Colorectal Cancer Screening Adherence of Medicare Fee-For-Service Beneficiaries Age 76 to 95 Years" recently published at the Journal of Oncology Practice reports the trends in overuse of CRC sc...

PIWI-interacting RNAs (piRNAs) are another subgroup of small non-coding emerging as key players in different biological activities, including regulating gene and protein expression, epigenetic silencing transposable elements, controlling the spermatogenesis by interacting with PIWI proteins. Recently, help next-generation sequencing, abnormal piRNA expression has been observed types cancer, suc...

Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer. In contrast, amplification of DYRK2 gene occurs in esophageal/lu...