consistent protective effect of regular use of non-steroidal anti-inflammatory drugs [6] and the important role of several pro-inflammatory cytokines during carcinogenesis [7] . Interestingly, the cyclooxygenase-2 enzyme, which is established as an effective chemoprevention target, is present predominantly in stromal cells, including macrophages, in ‘sporadic’ colorectal adenomas, reminiscent o...

Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. Although conclusive evidence is still lacking, epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has chemopreventive properties against CRC. Similarly, regular consumption of mesalazine, a drug structurally related to NSAIDs, seems to reduce the risk of CRC in patients...

The performance of combining fecal immunochemical tests (FITs) and a high-risk factor questionnaire (HRFQ) in colorectal cancer (CRC) screening in economically and medically underserved populations is uncertain. This study investigated the performance of a CRC screening protocol of combining FITs and an HRFQ as primary screening methods in a rural Chinese population. A CRC mass screening was co...

Evaluating colorectal lesions by means of radiographic imaging continues to play a major role in detecting and staging cancer of the lower gastrointestinal tract. The diagnosis of large bowel lesions namely Colitis, Vascular and Neoplasm had traditionally been made on the basis of barium enema and/or colonoscopy. Cross sectional imaging as Computed tomography scanning (CT) and MRI plays a pivot...

a set of one hundred and twenty nine patients with known primary malignancy and suspected brain metastasis was reviewed in present study. the patients were selected among patients presented to the mri section of imam khomeini hospital or a private mri center in tabriz (iran). primary tumor site, clinical manifestations, number and site of lesions were identified in this patient population. the ...

BACKGROUND Activated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity. MATERIAL A...

Received 31 March 2006 Accepted for publication 31 March 2006 . . . . . . . . . . . . . . . . . . . . . . . 1.0 INTRODUCTION There has been increasing recognition of the potential benefits of liver resection for colorectal metastases in the UK although this treatment has been established more widely in other Western countries. There are no randomised studies assessing outcome following resectio...

Serial estimations of plasma carcinoembryonic antigen (C.E.A.) levels have been carried out in 220 patients with colorectal carcinomas who had potentially and apparently curative surgery. In a two-year follow-up period 53 patients developed recurrences or metastases. In 36 of these patients sustained rises in plasma C.E.A. titres occurred synchronously with or between three and 18 months before...