AUC is an important parameter in pharmacokinetic studies. There are different ways to calculate AUC. Sometime, the statistician or pharmacokineticist has to choose one particular method to calculate AUC depending on the actual concentration data. Among many pharmacokinetic approaches and modeling analyses, traditional trapezoidal, log-linear trapezoidal, Lagrange polynomial integration, and Pur...

1. We cut serial sections through the medial part of the rat vestibular macula for transmission electron microscopic (TEM) examination, computer-assisted three-dimensional (3-D) reconstruction, and compartmental modeling. The ultrastructural research showed that many primary vestibular neurons have an unmyelinated segment, often branched, that extends between the heminode [putative site of the ...

Social hierarchies are ubiquitous in social groups such as human societies and insect colonies; however, the factors that maintain these less clear. Motivated by shared reproductive hierarchy of ant species Harpegnathos saltator, we have developed simple compartmental nonlinear differential equations to explore how key life-history metabolic rate parameters may impact determine its colony size ...

Background: This paper presents a newly developed Matlab code for the numeri- cal simulation of compartmental/deterministic models. It addresses modeling and issues concerning compartmental The is easy to under- stand and edit An alternative codes for statistical software package R has been proposed same mod...

UNLABELLED The aim of this study was to investigate whether compartmental modeling of 1-(11)C-glucose PET kinetics can be used for noninvasive measurements of myocardial glucose metabolism beyond its initial extraction. METHODS 1-(11)C-Glucose and U-(13)C-glucose were injected simultaneously into 22 mongrel dogs under a wide range of metabolic states; this was followed by 1 h of PET data acqu...

OBJECTIVE We determined the postoperative pharmacokinetics (PK), safety, and analgesic effects of ketorolac in 14 infants (aged <6 months) receiving a single intravenous (IV) administration of racemic ketorolac or placebo. BACKGROUND Information on the PK of ketorolac in infants is limited. Unblinded studies suggest ketorolac may be useful in infants. METHODS This double-blinded, placebo-co...

Multi-compartmental models of neurons provide insight into the complex, integrative properties of dendrites. Because it is not feasible to experimentally determine the exact density and kinetics of each channel type in every neuronal compartment, an essential goal in developing models is to help characterize these properties. To address biological variability inherent in a given neuronal type, ...