We consider the situation where a number of firms decide their individual capacity investment levels. The total sum of these levels determines the total return, which the firms share in proportion to their contributions. Prior to their commitments, firms may spend efforts on learning a size indicator of the market. Using this model, we can explain the over-capacity phenomenon that appeared time...

Abstract: A new chaotic memory search model based on associative dynamics using features in stored patterns is proposed. In the present paper, two kinds of features are considered; external and internal ones. The former is assigned by a designer and the latter is automatically assigned by competitive learning. The control of chaotic and static states is realized using a presynaptic inhibition m...

Peptide-protein interactions have critical roles in biology. Monitoring peptide-protein interactions plays an important role in investigating molecular recognition, screening drugs, and designing biosensors. In this paper, we develop a novel fluorescent approach to monitor peptide-protein interactions based on the assembly of pyrene-labeled peptide and graphene oxide (GO). The pyrene-labeled pe...

It is shown that the work function algorithm for the 2-evader problem has competitive ratio m ? 2 for all metric spaces with m points. This settles the k-server conjecture for metric spaces with k+2 points.

An online domain-independent competitive gaming system, called JOYCE, was devised to engage students in drill-and-practice exercises. In this paper, theories underpinning the system design are explained. As in the system students are allowed to compete with others in a face-to-face situation, and in network situations where an opponent’s identify is revealed or concealed, a preliminary study wa...

Hierarchical in silico screening protocols against the agonist bound acetylcholine binding protein (AChBP) crystal structure were efficient in identifying novel chemotypes for AChBP and the human α7 receptor. Two hit structures were cocrystallized with AChBP revealing intermolecular cation-π interactions with loop C but lacking intermolecular hydrogen bonding. The compounds act as competitive α...

The influence of ketamine upon human plasma cholinesterase (E.C. 3.1.1.8) was determined by means of a colorimetric assay technique at 25 degrees C, pH 7.7 with butyrylthiocholine as substrate. Ketamine caused a reversible inhibition of cholinesterase (pI50= 2.75; apparent Ki=4.94X10(-4) M). The kinetic analysis of the inhibitory action revealed a mixed competitive/non-competitive type of mecha...

We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are either competitive or uncompetitive inhibitors with respect to substrate peptides. In this report, we demonstrate how the interactions between PKC and inhibitors change PKC activation kinetics. A substrate competitive inhibitor, bisindolylmaleimide I, targets activated PKC and stabilizes PKC in the activated ...

A rapid method for the synthesis of DNA fragments for competitive PCR analysis is described. This procedure takes advantage of the fact that if PCR is carried out with a mixture of re-ligated restriction digestion fragments, only those fragments containing binding sites for both PCR primers will be amplified. Following electrophoresis of the amplified mixture, the DNA fragment of desired size c...