نتایج جستجو برای: concentration factor
تعداد نتایج: 1189546 فیلتر نتایج به سال:
OBJECTIVE To determine whether intestinal epithelial cells have a receptor for intestinal trefoil factor and characterize receptor-ligand binding kinetics. METHODS Radioligand binding assays were performed to characterize the binding kinetics between [(125)I]-labeled ITF and IEC-6, HT-29, Caco2 and HaCaT cells. The K d, Bmax and other kinetic variables describing the interaction between ITF a...
A series of novel benzohydrazide derivatives containing dihydropyrazoles have been synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their biological activities as potential antiproliferative agents have been evaluated. Among these compounds, compound H20 exhibited the most potent antiproliferative activity against four cancer cell line variants (A549, MCF-7...
In order to assess the psychometric properties of the Brazilian version of the FFMQ, 395 participants divided into smokers, people from the general population, college students, and meditators answered the FFMQ and the Psychological Well-Being Scale (PWBS). An Exploratory Factor Analysis (EFA) was conducted and the reliability was assessed. The FFMQBR consists of seven factors and all of them s...
The interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved us to search for peptide derivatives able to block this protein-protein interaction. In a previous work we had described a collection of linear 13-mer peptides specially designed to adopt helical conformations (Ac-SSEEX⁵ARNX⁸AAX12N-NH₂), ...
In this research, residual strength and stress concentration factor of laminated composites with a circular open hole are studied analytically, numerically and experimentally. The numerical study was carried out using the finite element method. Moreover an analytical study was carried out with developing of point stress criterion. Mechanical testing was performed to determine the un-notched ten...
To study the effects of potassium (K) and zinc (Zn) with cadmium (Cd) in roots, stem, leaves and fruits of tomato plants, a greenhouse experiment was conducted as factorial based on complete random blocks design. The first factor was Zn at three levels (88.8, 177.6 and 355.2 μg/L) and the second factor was K at three levels (255, 510 and 1020 mg/L). In this experiment, the basic nutrition solut...
Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identif...
Factor XIa (fXIa) is being recognized as a prime target for developing safer anticoagulants. To discover synthetic, small, allosteric inhibitors of fXIa, we screened an in-house, unique library of 65 molecules displaying many distinct scaffolds and varying levels of sulfation. Of these, monosulfated benzofurans were the only group of molecules found to inhibit fXIa (∼100% efficacy) and led to t...
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