To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place prefe...

The highlight for November is by David Booth in the School of Psychology at the University of Birmingham in England. When reflecting on the individuals who have made impacts on the general field of taste aversion learning, I have always included Dr. Booth as one of the major players. It is interesting in this context that while much of his research has addressed conditioned taste aversions (see...

Recent evidence suggests that cannabinoid CB(1) receptors may represent effective targets for therapeutic agents used to treat cocaine and heroin relapse. However, the role of cannabinoid CB(1) receptors in the potential treatment for other drugs of abuse is still largely unknown. The present study was conducted to determine whether cannabinoid CB(1) receptors play a similar role in relapse to ...

SUMMARY In this manuscript we present a methodology for reducing the impact of the hosting room reflections in sound field rendering applications based on loudspeaker arrays. The problem is formulated in a least-squares sense. Since matrices involved in the problem are ill-conditioned, it is important to devise a suitable technique for the regularisation of the pseudo-inverse. In this work we a...